Cases of cold damage diseases recorded in TCM classic book-On Cold Damage introduced the general scope and identification methods of epidemic diseases. TCM doctors in Ming and Qing dynasties paid more attention to the induction and summary of therapeutic methods and formulas and pursued clinical practicality. With in-depth thinking from different angles such as the name and nature of the disease, the rules of treatment and clinical thinking mode, etc., it is believed that the ancient experience of syndrome differentiation and treatment of epidemic diseases can still guide our clinical practice today.