Objective:To observe the effect of total flavonoids in stigmata maydis(TFSM) on the concentration of serum uric acid(SUA) and other related metabolic indexes as well as insulin resistance(IR) state in rat models of insulin resistance complicated with hyperuricemia(IR-HUA rat models). Methods60 male SD rats were randomly divided into the normal control group(Control group),the IR-HUA model group(IR-HUA group),the pioglitazone positive control group(Pioglitazone group),the benzbromarone positive control group(Benzbromarone group),the TFSM high dose group(TFSM.H group) and the TFSM low dose group(TFSM.L group). The Control group was fed with the ordinary feed and drinking water. The other groups were fed with high energy feed and drinking 10% fructose water for 8 weeks. At the beginning of the 7th week(d43),the Control group and the IR-HUA group were given intragastric administration of 2% Tween 80 CMC-Na, and the other groups were given the corresponding medicine solution once a day for 15 days; 3-4 h after intragastric administration,the Control group was given intragastric administration of 0.5% CMC-Na solution,the other groups were given adenine solution(150 mg/kg body mass) once a day for 15 days.  Results:Compared with the Control group, in the IR-HUA group, the Lee’s index, the fraction excretion of uric acid(FEUA), the fasting plasma glucose (FPG) and the HOMA-IR index increased, and the fasting insulin (FINS) increased slightly. Compared with the IR-HUA group, the body length of the Benzbromarone group increased and the Lee’s index decreased; the concentrations of SUA and the urine uric acid(UUA) in the Benzbromarone group, TFSM.H group and TFSM.L group decreased slightly, while the urination volume increased slightly. The total uric acid excretion decreased slightly in the Pioglitazone group, Benzbromarone group, TFSM.H group and TFSM.L group, but FEUA increased slightly in the Pioglitazone group, Bebzbrommarone group and TFSM.L group. And the FPG, FINS, HOMA-IR index of the Pioglitazone group, Benzbromarone group, TFSM.H group and FINS of the TFSM.L group decreased slightly. In addition, the concentration of SUA in the Benzbromarone group and TFSM.H group was correlated with FEUA.  Conclusion:In IR-HUA model rats,the increase of SUA concentration was accompanied by the increase of FPG concentration,Lee’s index and HOMA-IR index. The results suggested that the IR-HUA rat model is successful. TFSM,pioglitazone and benzbromarone all showed a certain trend of promoting renal excretion of uric acid,reducing SUA concentration and improving IR state in the model rats. The SUA concentration is closely related to the renal uric acid excretion capacity.