This article explores the pathogenesis and treatment of high-risk human papilloma virus(HPV)infection in traditional Chinese medicine. It is believed that the disease is primarily caused by the deficiency of vital qi while dampness, heat, stasis and poison are the secondary,and the poison damages Chong and Ren and knots in the uterus. It results in abnormality of color,quality and smell in leucorrhea. The clinical symptoms are complicated,even accompanied by vulvar warts and pruritus. Clinical treatments should be adjusted according to the syndrome,such as clearing heat and removing dampness to treat liver depression and spleen suppression,damp-heat flowing down; strengthening vital qi and removing pathogenic factors to eliminate deficiency and evil lingering,as well as dampness, heat, stasis and poison; internal and external treatment to remove condyloma acuminatum.