Objective:To explore the syndrome elements and medication rules of gastroesophageal reflux disease (GERD) based on data mining. MethodsDatabases of China National Knowledge Network (CNKI), VIP and WanFang Data were searched, and relevant literatures from January 2010 to January 2020 were included. Excel databases containing syndrome elements of disease location, disease nature and medication was established. SPSS 20.0 was used for frequency analysis of Chinese herbal medicines (CHMs), and SPSS Modeler 18.0 was used for relational network model analysis and cluster analysis of relevant data.  Results:①A total of 204 literatures were included, involving 364 prescriptions of traditional Chinese medicine. ②Through frequency analysis, 7 syndrome elements of disease location and 14 syndrome elements of disease nature were screened out. Stomach, liver and spleen were the top three syndrome elements of disease location with the highest frequency, while qi stagnation, qi deficiency and fire were the top three syndrome elements of disease nature with the highest frequency. ③Among the included 364 proved prescriptions, 208 CHMs were involved. There are 26 CHMs whose usage frequency was more than 10% of the total usage frequency, namely Gancao (Glycyrrhiza Glabra), Banxia (Rhizoma Pinelliae), Huanglian (Rhizoma Coptidis), Chaihu (Radix Bupleuri), Fulin (Poria Cocos), Chenpi (Pericarpium Citri Reticulatae), Wuzhuyu (Fructus Evodiae), Haipiaoxiao (Endoconcha Sepiae), Baishao (Radix Paeoniae Alba), Baizhu (Rhizoma Atractylodis Macrocephalae), Zhike (Fructus Aurantii), Houpo (Cortex Magnoliae Officinalis), Xuanfuhua (Flos Inulae), Dangshen (Radix Codonopsis), Huangqin (Radix Scutellariae), Zhebeimu (Bulbus Fritillariae Thunbergii), Daizheshi (Ochra Haematitum), Xiangfu (Rhizoma Cyperi), Duanwalengzi (Concha Arcae Preparata), Zhishi (Fructus Aurantii Immaturus), Sharen (Fructus Amomi), Ganjiang (Rhizoma Zingiberis), Zhuru (Caulis Bambusae in Taeniam), Zhizi (Fructus Gardeniae), Yujin (Radix Curcumae) and Shengjiang (Zingiber officinale). ④The results of correlation analysis showed that CHMs groups with higher support were Huanglian (Rhizoma Coptidis)-Wuzhuyu (Fructus Evodiae)-Chaihu (Radix Bupleuri), Huanglian (Rhizoma Coptidis)-Wuzhuyu (Fructus Evodiae)-Haipiaoxiao (Endoconcha Sepiae), Huanglian (Rhizoma Coptidis)-Wuzhuyu (Fructus Evodiae)-Banxia (Rhizoma Pinelliae)-Gancao (Glycyrrhiza Glabra), and Chaihu (Radix Bupleuri)-Zhike (Fructus Aurantii)-Baishao (Radix Paeoniae Alba).  Conclusion:With stomach as the disease location, GERD is also closely related to liver and spleen. Qi stagnation, Qi deficiency and fire are the main syndrome elements of disease nature. The pathogenesis of GERD is mixed with deficiency and excess, together with the intermingling of cold and heat. When it comes to the treatment, the main methods are soothing liver and purging heat, harmonizing stomach and lowering adverse qi, invigorating spleen and supplementing qi. Once the transportation and transformation function of the middle energizer is restored, the clear qi will ascend and the turbid qi will descend spontaneously.