Objective:To analyzes the rules of Professor Tang Hanjun’s internal and external treatment methods for complex sinuses, and summarize his academic thoughts through data mining methods. MethodsThe medical records of Professor Tang Hanjun’s treatment of complex sinuses were sorted out, and TCM clinical diagnosis and treatment information database of complex sinuses was established. Data mining technologies such as frequency analysis and correlation analysis were used to analyze the general characteristics of patients, the compatibility rules of formulas in internal treatment and the use of external treatment methods.  Results:①The study included 265 medical records. Among 265 patients, there were more males than females, with a median age of 55 years old and a median course of disease of 210 days. A total of 136 cases (51.32%) were complicated with diabetes, viral hepatitis B and other diseases. The most commonly affected area was chest wall (34.7%), and surgery (64.53%) and infection (23.40%) were common causes. According to syndrome differentiation and classification of traditional Chinese medicine (TCM), incompletely removed residual toxin syndrome was the most common syndrome(78.87%), followed by dual deficiency of qi and blood syndrome (20.38%), but vital qi deficiency and lingering toxin syndrome was relatively rare (0.75%). ②A total of 229 patients received TCM treatment orally, involving 229 kinds of medicinals, with a total use frequency of 4,234 times. A total of 13 kinds of medicinals were used more than 100 times, mainly focusing on medicinals for invigorating qi and spleen, invigorating spleen and activating blood circulation, and invigorating qi and removing dampness. ③The results of correlation analysis showed that the most commonly used pair compatibility combinations were mainly medicinals for invigorating qi and spleen, invigorating spleen and activating blood circulation, and invigorating qi and removing dampness. The compatibility combinations of three medicinals mainly included combinations of medicinals for invigorating spleen and nourishing blood, invigorating spleen and activating blood circulation, invigorating qi and spleen, invigorating spleen and removing dampness, invigorating spleen and expelling toxin. The compatibility combinations of four medicinals were mainly the combinations of raw Huangqi (Radix Astragali), Baizhu (Rhizoma Atractylodis Macrocephalae), Fulin (Poria Cocos) and medicinals for removing dampness, activating blood circulation and expelling toxin by supporting vital qi. The compatibility combinations of five medicinals was the combination of medicinals for invigorating qi, invigorating spleen, strengthening vital qi, cooling blood, activating blood circulation and eliminating stagnation composed of raw Huangqi (Radix Astragali), Baizhu (Rhizoma Atractylodis Macrocephalae), Fulin (Poria Cocos), Chishao (Radix Paeoniae Rubra) and Danshen (Radix Salviae Miltiorrhizae). ④Commonly used external treatment methods included dusting powdered drugs, plastering and application, flushing and infusing therapy, corrosive drug stick, and drainage through gauze, etc.  Conclusion:Professor Tang Hanjun attaches great importance to strengthening vital qi in the treatment of complex sinuses, especially the supplementation of spleen and stomach. He applies the methods of tonifying, dredging and regulating qi, blood, channels and collaterals while expelling and removing toxins, which embody his academic thought of treating complex sinuses by strengthening vital qi. Various external treatment methods are flexibly used with the internal treatment methods to achieve satisfactory therapeutic effects.