Objective:To study the clinical effect of Huatan Qufeng (resolving phlegm and dispelling wind) Prescription on chronic cough (phlegm-dampness syndrome) in children after respiratory tract infection. MethodsA total of 92 children with chronic cough (phlegm-dampness syndrome) after respiratory tract infection were randomly divided into control group and treatment group, 46 cases in each group. The control group was given montelukast sodium chewable tablets, and ambroxol oral solution was added to patients with severe cough. The treatment group was given Huatan Qufeng Prescription in granule form for oral intake. The course of treatment was 14 days in both groups. The clinical symptoms, signs, cough visual analogue scale (VAS) and serological indexes (leukocyte, hemoglobin, eosinophil count) were observed to evaluate the clinical efficacy and safety.  Results:①There were significant differences in VAS between two time points (D5 and D0, D10 and D5, D14 and D10) in the treatment group (P<0.05); In the control group, there were significant differences in VAS between two time points (D5 and D0, D10 and D5, D14 and D10) (P<0.05); Compared between the two groups at the same observation time points, differences in VAS at D5, D10 and D14 were statistically significant (P<0.05). ②There were significant differences in the total score of main symptoms, the total score of secondary symptoms and the quantitative score of physical signs before and after treatment in both groups (P<0.05); After treatment, the total score of main symptoms, the total score of secondary symptoms and the quantitative score of cough physical signs of the treatment group were less than those of the control group (P<0.05). ③The total effective rates of the main symptoms in the treatment group and the control group were 87.0% and 65.2% respectively, and the difference between the two groups was statistically significant (P<0.05); The total effective rates of secondary symptoms in the treatment group and the control group were 89.1% and 60.9% respectively, and the difference between the two groups was statistically significant (P<0.05); The total effective rates of quantitative evaluation of cough signs in the treatment group and the control group were 69.6% and 39.1% respectively, and the difference between the two groups was statistically significant (P<0.05). ④After treatment, there was no significant difference in leukocyte and hemoglobin indexes between the two groups (P>0.05). The absolute eosinophil count in the treatment group was lower than that in the control group (P<0.05). ⑤In the course of study, 2 cases of adverse reactions occurred in the treatment group and 3 cases in the control group. There was no significant difference in adverse reactions between the two groups (P>0.05).  Conclusion:Huatan Qufeng Prescription can effectively reduce the frequency and degree of cough and expectoration in children with chronic cough (phlegm-dampness syndrome) after respiratory tract infection, and improve their mental state, diet, defecation and other related symptom groups. The curative effect is remarkable, safe and effective, and is worthy of clinical application and further standardized research.