Clinical evaluation of Jiawei Jinning formula in inhibiting postoperative recurrence of ground-glass early lung cancer

YU Qiquan; BAO Qi; WU Chunxiao; ZHANG Huiyong; YOU Shengfu; ZHANG Zeliang; ZHANG Kun; LI Yang; SHOU Weizhen; YAN Xiaoyun

doi:10.16305/j.1007-1334.2020.2001027

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Clinical evaluation of Jiawei Jinning formula in inhibiting postoperative recurrence of ground-glass early lung cancer

更新时间：2022-08-31

- Clinical evaluation of Jiawei Jinning formula in inhibiting postoperative recurrence of ground-glass early lung cancer
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 12, Pages: 50-53(2020)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院胸外科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.2001027
  CLC：
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YU Qiquan, BAO Qi, WU Chunxiao, et al. Clinical evaluation of Jiawei Jinning formula in inhibiting postoperative recurrence of ground-glass early lung cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 54(12):50-53(2020)
DOI：

YU Qiquan, BAO Qi, WU Chunxiao, et al. Clinical evaluation of Jiawei Jinning formula in inhibiting postoperative recurrence of ground-glass early lung cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 54(12):50-53(2020) DOI： 10.16305/j.1007-1334.2020.2001027.

摘要

目的：观察加味金宁方对磨玻璃样早期肺癌术后复发的抑制作用。方法：将72例磨玻璃样早期肺癌术后患者随机分为治疗组和对照组,每组36例。治疗组服用加味金宁方,对照组服用1/20剂量加味金宁方。两组均连续服药1年或至病情进展,观察实体瘤疗效、免疫疗效,比较中医证候积分的变化情况。结果：①试验过程中治疗组、对照组各脱落3例,最终有效完成试验的病例66例,治疗组、对照组各33例。②实体瘤疗效:在术后1年内,治疗组、对照组的疾病控制率分别为93.94%、72.73%；治疗组实体瘤疗效优于对照组(P<0.05)。③免疫疗效:术后3个月治疗组、对照组有效率分别为75.76%、69.70%,两组免疫疗效差异无统计学意义(P>0.05)；术后6个月、术后9个月、术后12个月两组免疫疗效比较,治疗组优于对照组(P<0.05)。④治疗后,两组中医证候积分均呈持续下降趋势,与本组前一观察时点比较,差异有统计学意义(P<0.05)；术后6个月、术后9个月、术后12个月组间比较,治疗组中医证候积分低于对照组(P<0.05)。结论：加味金宁方对磨玻璃样早期肺癌术后复发具有一定的抑制作用,且有助于促进机体免疫功能的恢复,并改善中医证候,值得临床推广应用。

Abstract

Objective:To observe the inhibitory effect of Jiawei Jinning formula on postoperative recurrence of ground-glass early lung cancer. MethodsSeventy-two patients with ground-glass early lung cancer were randomly divided into treatment group and control group after operation, 36 cases in each group. The treatment group was administered Jiawei Jinning formula, while the control group was administered 1/20 dose of Jiawei Jinning formula. Both groups were treated continuously for 1 year or until the disease progression occurred to observe response evaluation in solid tumors and immune efficacy, as well as the comparison of the changes of TCM syndrome scores. Results:①During the trail, there were 3 dropout cases in the treatment group and 3 dropout cases in the control group, and 66 cases finally completed the test, 33 cases in each group. ②Response evaluation in solid tumor: within one year after operation, the disease control rates of the treatment group and the control group were 93.94% and 72.73%, respectively. The curative effect of treatment group was better than that of control group (P<0.05). ③Immune efficacy: three months after operation, the effective rates of the treatment group and the control group were 75.76% and 69.70%, respectively. There was no significant difference in immune efficacy between the two groups (P>0.05). Comparisons of the immune efficacy were made between the two groups 6 months, 9 months and 12 months after operation respectively, and each time the treatment group showed better immune efficacy than that of the control group (P<0.05). ④ After treatment, the TCM syndrome scores in the two groups showed a continuous downward trend, and the difference was statistically significant compared with the scores in the previous observation time point (P<0.05). Comparisons of TCM syndrome scores between the two groups 6 months, 9 months and 12 months after operation showed that TCM syndrome scores in the treatment group was lower than those in the control group (P<0.05). Conclusion:Jiawei Jinning formula can inhibit the postoperative recurrence of ground-glass early lung cancer to some extent, contribute to the recovery of immune function and improve TCM syndromes, which is worthy of clinical application.

关键词

早期肺癌磨玻璃结节金宁方术后复发免疫功能中医药疗法

Keywords

early lung cancerground-glass noduleJinning formulapost-operation recurrenceimmune functionTCM therapy

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