Advances in neuroprotective mechanism of paeoniflorin

CONG Chao; ZHANG Yue; LI Shengnan; WANG Yuejiao; LIU Huicong; XU Lianwei

doi:10.16305/j.1007-1334.2020.1911108

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Advances in neuroprotective mechanism of paeoniflorin

更新时间：2022-08-31

- Advances in neuroprotective mechanism of paeoniflorin
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 11, Pages: 93-97(2020)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院妇科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.1911108
  CLC：
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CONG Chao, ZHANG Yue, LI Shengnan, et al. Advances in neuroprotective mechanism of paeoniflorin. [J]. Shanghai Journal of Traditional Chinese Medicine 54(11):93-97(2020)
DOI：

CONG Chao, ZHANG Yue, LI Shengnan, et al. Advances in neuroprotective mechanism of paeoniflorin. [J]. Shanghai Journal of Traditional Chinese Medicine 54(11):93-97(2020) DOI： 10.16305/j.1007-1334.2020.1911108.

摘要

综述近10年芍药苷的神经保护作用研究进展。芍药苷在神经系统中具有广泛的药理作用,主要包括抗神经细胞氧化(如降低氧自由基水平、调节一氧化氮及诱导型一氧化氮合酶含量和活化腺苷A1受体)、防止线粒体损伤、调节MAPK、PI3K/Akt、Nrf2/ARE信号转导通路、防止钙离子内流、调节自噬、抑制神经炎症等。

Abstract

To summarize the research progress of paeoniflorin(PF)in neuroprotection in the past decade. Paeoniflorin has a wide range of pharmacological effects in the nervous system,mainly including anti-oxidation of nerve cells(such as reducing the level of oxygen free radicals,regulating the content of nitric oxide and inducible nitric oxide synthase,and activating adenosine A1 receptors),preventing mitochondrial damage,regulating MAPK,PI3K/Akt,Nrf2/ARE signal transduction pathway,preventing calcium influx,regulating autophagy,inhibiting neuroinflammation,etc.

关键词

芍药苷神经保护作用氧化应激细胞凋亡自噬炎症因子综述

Keywords

paeoniflorinneuroprotectionoxidative stressapoptosisautophagyinflammatory factorreview

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