Objective:To scientifically evaluate TCM efficacy evaluation scale for qi deficiency syndrome, and lay a foundation for the clinical application and promotion of the scale. MethodsThe feasibility (acceptance rate, completion rate, filling time and ceiling and floor effects), reliability (internal consistency reliability and test-retest reliability), validity (content validity, structure validity and criterion validity) and responsiveness of the TCM efficacy evaluation scale for Qi deficiency syndrome were evaluated by epidemiological investigation.  Results:①The acceptance rate of the scale was 95.83%, the completion rate was 100%, and the average completion time was 2.2 minutes. No ceiling and floor effects were found in all items. ②The test-retest reliability of the total table was 0.954, and the retest reliability of 10 items was greater than 0.7; The Cronbach coefficient of the general table, fatigue dimension, shortness of breath dimension and mental fatigue dimension was 0.827,0.674,0.768 and 0.614 respectively. The correlation coefficient between the dimension score of each item and the total score of the scale was greater than 0.4 except item 2. ③Three factors were screened out through factor analysis, with a cumulative contribution rate of 62.358%. Among them, the factor analysis of item 8 was different from the assumption framework, but the original scale structure was still retained after expert group discussion. The total score of the scale, fatigue dimension score, shortness of breath dimension score and mental fatigue dimension score showed negative correlations with the hemoglobin level. ④The scale score of Qi deficiency syndrome group was higher than that of healthy group, and the difference was statistically significant (P<0.01).  Conclusion:TCM efficacy evaluation scale for qi deficiency syndrome has good feasibility, reliability, validity and responsiveness, and can be used as a quantifiable measurement tool for clinical efficacy evaluation of patients with qi deficiency syndrome.