Clinical observation on Dengzhan Shengmai Capsule combined with conventional therapy in treating coronary atherosclerotic heart disease with hyperlipidemia (qi deficiency and blood stasis syndrome)

LOU Xusheng; LI Ping

doi:10.16305/j.1007-1334.2020.1910011

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Clinical observation on Dengzhan Shengmai Capsule combined with conventional therapy in treating coronary atherosclerotic heart disease with hyperlipidemia (qi deficiency and blood stasis syndrome)

更新时间：2022-08-31

- Clinical observation on Dengzhan Shengmai Capsule combined with conventional therapy in treating coronary atherosclerotic heart disease with hyperlipidemia (qi deficiency and blood stasis syndrome)
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 12, Pages: 45-49(2020)
- 作者机构：
  
  1. 北京中医药大学第三附属医院心血管内科,北京,100029
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.1910011
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LOU Xusheng, LI Ping. Clinical observation on Dengzhan Shengmai Capsule combined with conventional therapy in treating coronary atherosclerotic heart disease with hyperlipidemia (qi deficiency and blood stasis syndrome). [J]. Shanghai Journal of Traditional Chinese Medicine 54(12):45-49(2020)
DOI：

LOU Xusheng, LI Ping. Clinical observation on Dengzhan Shengmai Capsule combined with conventional therapy in treating coronary atherosclerotic heart disease with hyperlipidemia (qi deficiency and blood stasis syndrome). [J]. Shanghai Journal of Traditional Chinese Medicine 54(12):45-49(2020) DOI： 10.16305/j.1007-1334.2020.1910011.

摘要

目的：观察灯盏生脉胶囊联合常规疗法治疗气虚血瘀型冠状动脉粥样硬化性心脏病(以下简称“冠心病”)伴高脂血症的临床疗效。方法：将90例气虚血瘀型冠心病伴高脂血症患者随机分为对照组和观察组,每组45例。对照组给予基础常规疗法,观察组在对照组治疗措施的基础上加用灯盏生脉胶囊。两组疗程均为2个月,观察临床疗效,比较血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、血脂水平及中医证候积分的变化情况。结果：①观察组、对照组总有效率分别为88.9%、57.8%,观察组临床疗效优于对照组(P<0.05)。②治疗前后组内比较,两组中医证候总积分及各分项积分均降低(P<0.05)；组间治疗后比较,观察组中医证候总积分及各分项积分低于对照组(P<0.05)。③组内比较,两组治疗后心绞痛发作次数及持续时间均较治疗前减少(P<0.05)；组间治疗后比较,观察组心绞痛发作次数及持续时间均少于对照组(P<0.05)。④治疗前后组内比较,观察组Hcy、hs-CRP、TG、LDL-C、HDL-C水平差异有统计学意义(P<0.05),对照组hs-CRP、TG、LDL-C、HDL-C水平差异有统计学意义(P<0.05)；组间治疗后比较,Hcy、hs-CRP、TG、LDL-C、HDL-C水平差异均有统计学意义(P<0.05)。⑤两组均未见明显不良反应发生。结论：与单纯采用常规疗法相比,加用灯盏生脉胶囊治疗气虚血瘀型冠心病伴高脂血症疗效满意,可明显改善患者的心绞痛症状及机体炎症状态,调节血脂水平。

Abstract

Objective:To observe the clinical effect of Dengzhan Shengmai Capsule combined with conventional therapy on coronary atherosclerotic heart disease (hereinafter referred to as “coronary heart disease”) with hyperlipidemia (qi deficiency and blood stasis syndrome). MethodsNinety patients with coronary heart disease (CHD) accompanied with hyperlipidemia (qi deficiency and blood stasis syndrome) were randomly divided into control group and observation group, 45 cases in each group. The control group was given basic conventional therapy, while the observation group was also given Dengzhan Shengmai Capsule besides the conventional therapy. The course of treatment was 2 months in both groups. The clinical efficacy was observed and the level changes of serum homocysteine (Hcy), high sensitivity C-reactive protein (hs-CRP), blood lipid and TCM syndrome scores were compared. Results:①The total effective rates of the observation group and the control group were 88.9% and 57.8%, respectively, and the clinical efficacy of the observation group was better than that of the control group (P<0.05). ②The total score of TCM syndromes and the score of each sub-item in the two groups decreased after treatment (P<0.05). The total score of TCM syndromes and the score of each sub-item in the observation group were lower than those in the control group (P<0.05). ③The frequency and duration of angina attacks decreased in both groups after treatment (P<0.05). Compared with the control group after treatment, the observation group had less frequency of angina attacks and shorter duration of angina attacks (P<0.05). ④There were significant differences in levels of Hcy, hs-CRP, TG, LDL-C and HDL-C in the observation group before and after treatment (P<0.05), while there were significant differences in levels of hs-CRP, TG, LDL-C and HDL-C in the control group before and after treatment (P<0.05). After treatment, the differences in levels of Hcy, hs-CRP, TG, LDL-C and HDL-C between two groups were significant (P<0.05). ⑤No significant adverse reactions occurred in both groups. Conclusion:Compared with conventional therapy alone, Dengzhan Shengmai Capsule is effective in treating coronary heart disease with hyperlipidemia (qi deficiency and blood stasis syndrome), which can significantly improve angina symptoms and inflammatory state of patients and regulate blood lipid level.

关键词

冠状动脉粥样硬化性心脏病高脂血症气虚血瘀灯盏生脉胶囊

Keywords

coronary atherosclerotic heart diseasehyperlipidemiaqi deficiency and blood stasisDengzhan Shengmai Capsule

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