Research progress on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine

XIONG Zhenfei; TANG Yanghua; LI Jinlong; TANG Dezhi

doi:10.16305/j.1007-1334.2020.08.012

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Research progress on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine

更新时间：2022-08-31

- Research progress on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 8, Pages: 89-93(2020)
- 作者机构：
  
  1. 浙江省杭州市萧山区中医院骨伤科,浙江,杭州,311201
  2. 上海中医药大学附属龙华医院骨科,上海,200032
  3. 上海中医药大学脊柱病研究所,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.08.012
  CLC：
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XIONG Zhenfei, TANG Yanghua, LI Jinlong, et al. Research progress on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 54(8):89-93(2020)
DOI：

XIONG Zhenfei, TANG Yanghua, LI Jinlong, et al. Research progress on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 54(8):89-93(2020) DOI： 10.16305/j.1007-1334.2020.08.012.

摘要

综述锌离子-锌离子转运蛋白8-金属调节转录因子1(Zinc-ZIP8-MTF1)信号通路调控骨性关节炎发生发展及中医药作用机制的研究进展。Zn,2+,稳态、锌转运蛋白以及锌离子依赖性转录因子与软骨损伤密切相关,Zinc-ZIP8-MTF1信号通路可调控骨性关节炎的发生、发展。目前中医药领域的相关研究局限于对Zn,2+,水平的调控,未涉及对ZIP8和MTF1的影响,因此研究中医药对Zinc-ZIP8-MTF1信号通路的影响对治疗骨性关节炎有重要意义。

Abstract

The progress was reviewed on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine. There was an association of zinc(Zn2＋)homeostasis, Zn2＋transporters, and Zn2＋-dependent transcription factors with cartilage injury. Futhermore, the Zinc-ZIP8-MTF1 signal pathway could regulate the occurrence and development of osteoarthritis.Until now, the research of traditional Chinese medicine in this field is limited to the regulation of Zn,2+, level, and is unknown about the influence on ZIP8 and MTF1. Therefore, it has important role in the treatment for OA to study the effect of traditional Chinese medicine on zinc-zip8-mtf1 signal pathway.

关键词

骨性关节炎Zinc-ZIP8-MTF1信号通路基质金属蛋白酶中医药疗法综述

Keywords

osteoarthritisZinc-ZIP8-MTF1 signal pathwaymatrix metalloproteinasetraditional Chinese medicinereivew

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