Objective:To investigate the effects of chamomile ethanol extraction on the blood glucose of streptozotocin(STZ)-induced type 2 diabetes model mice. And anti-oxidation capacity of chamomile extracts in normal mice and the anti-oxidation in vitro were also determined. MethodsThe ethanol extraction(CT) of chamomile was extracted by refluxing with ethanol. The water extract(ST) of chamomile was extracted by decoction. And the total flavonoids(HT) of chamomile were purified by macroporousresin. High sugar and high fat diet combined with STZ was used to establish a type 2 diabetic mice model. High, medium and low dose ethanol extractions were given by gavage. Two weeks later, the changes of blood glucose and glucose tolerance before and after administration were detected. Normal mice were used for antioxidant experiments. High, medium and low dose of ST and CT and HT were given by gavage. After 21 days, SOD and MDA and GSH-PX were detected in the serum of mice. The scavenging rate of chamomile ethanol extractions on various free radicals was measured to evaluate in vitro antioxidant capacity of chamomile ethanol extractions.  Results:Compared with the model group, the metformin hydrochloride group and CT high and middle dose groups were significantly different(P,<,0.01, P,<,0.05). In the glucose tolerance experiment, compared with the model group, the blood glucose value of diabetic mice at each time point were reuduced significantly in Metformin hydrochloride group and CT high and middle groups(P,<,0.01, P,<,0.05). In the antioxidant experiment, compared with the normal group, the SOD and GSH-PX in the serum of mice were increased and the MDA content was reduced(P,<,0.01, P,<,0.05). In the antioxidant experiment in vitro, the extractions of chamomile at a concentration of 1.0 mg/mL showed its certain scavenging ability to DPPH· and O-,2,·, but it had no effect in scavenging ·OH radicals.  Conclusion:sChamomile extractions had good hypoglycemic and antioxidant effects.