Objective:To observe the ovulation induction effect of Yushen Tongluo Granule combined with clomiphene in treating infertility patients with polycystic ovary syndrome(PCOS) of kidney-essence insufficiency type. MethodsSixty-two infertility patients with PCOS of kidney-essence insufficiency type were included and randomly divided into the treatment group(31 cases) and the control group(31 cases). The patients in both groups were orally treated with clomiphene citrate tablet from the fifth day of the menstrual cycle or progesterone withdrawal bleeding, lasting for 5 days. Based on above, the patients in the treatment group were orally treated with Yushen Tongluo Granule and the patients in the control group were orally treated with Yushen Tongluo Granule placebo after menstruation, until ovulation.The treatment course of the two groups was 3 menstrual cycles.The clinical effect of the two groups was evaluated, the pregnancy outcomes and the scores of Chinese medical syndrome were compared between the two groups, the ovulation and the endometrial thickness of ovulatory period were monitored by transvaginal ultrasound, the levels of testosterone(T), follicle stimulating hormone(FSH), and luteinizing hormone(LH), and LH/FSH ratio in unpregnant patients were compared between the two groups before and after treatment.  Results:①After treatment, the total clinical effective rates of the treatment group and the control group were 96.8% and 90.3% respectively with a significantly statistical difference between the two groups(P<0.05), and the effect of the treatment group was better than that of the control group.②The ovulation rates of the treatment group and the control group were 91.5% and 75.9% respectively, and the ovulation rate of the treatment group was higher than that of the control group(P<0.05).③In the course of treatment, the clinical pregnancy rates of the treatment group and the control group were 54.8% and 35.5% respectively, with no statistical difference between the two groups(P>0.05).④After treatment, the scores of Chinese medical syndrome in the treatment group were significantly decreased(P<0.01), and the scores of the treatment group were lower than those of the control group(P<0.01).⑤During the first, second and third menstrual cycles of treatment, the endometrial thickness of ovulatory period in the treatment group was significantly thicker than that in the control group(P<0.01).⑥After treatment, the levels of T and LH, and LH/FSH ratio of the unpregnant patients in both groups were significantly decreased compared with treatment before(P<0.05), and the LH/FSH ratio in the treatment group was lower than that in the control group(P<0.05).  Conclusion:Yushen Tongluo Granule combined with clomiphene has a synergistic effect in the treatment of infertility patients with PCOS of kidney-essence insufficiency type, which can obviously enhance the ovulation rates, improve the Chinese medical syndrome, increase the endometrial thickness and improve the level of sex hormone, and its total clinical effect is better than that of clomiphene alone.