Objective:To retrospectively analyze the clinical efficacy and liver injury of 100 cases of coronavirus disease 2019 (hereinafter referred to as COVID-19) treated by integrated traditional Chinese and western medicine in Shanghai. MethodsWe collected the clinical data and treatment plan of 100 cases of COVID-19 admitted to Shanghai Public Health Clinical Center from January 22,2020 to February 10,2020, observed the tongue image, pulse condition, TCM syndromes, liver injury indexes, clinical outcome and prognosis, and compared the changes of clinical symptoms, inflammation and immune related indexes.  Results:①In this study, COVID-19 cases presented 3 main traditional Chinese medicine (TCM) syndromes:heat toxin blocking the lung, damp toxin stagnating the lung and qi deficiency of the lung and spleen. There were more cases of excess syndrome than cases of deficiency syndrome, and cases of the lung-spleen qi deficiency syndrome were more than cases of the dual deficiency of qi and yin syndrome. ② There were 43 asymptomatic cases (43.0%) at the time of admission. After taking TCM decoction, the main symptoms of 52 symptomatic cases, such as fever, cough, expectoration, poor appetite and diarrhea, were improved to varying degrees. ③There were significant differences in serum leukocyte count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and immune index (CD4,+,) before and after 1 week of TCM decoction treatment (P,<,0.05). ④A total of 16 cases had mild liver injury before the treatment of TCM decoction. By comparing the liver function indexes before and after 1 week of TCM treatment, we found that the liver function of 2 cases recovered to normal after treatment while the other 14 cases still had mild liver injury, and there was no significant difference in liver function indexes before and after treatment (P,>,0.05). The liver function indexes of the other 84 cases were within the normal range before and after 1 week of TCM decoction treatment. ⑤In this study, 81 cases (81.0%) recovered and were discharged from hospital and 19 cases (19.0%) were still under treatment with a mortality rate of 0%. The average hospitalization duration of discharged patients was (16.0±5. 8) days. Of 5 severe cases of COVID-19,3 cases recovered from the disease and were discharged from hospital. The remaining 2 cases turned to mild type and did not develop to critical type. The conversion rate of critical case was 0%. ⑥Of 81 cases discharged from hospital, only 5 cases (6.2%) showed complete absorption of pneumonia infection, and the remaining 76 cases (93.8%) showed abnormal lesions of different degrees on chest CT.  Conclusion:The integrated treatment of traditional Chinese and western medicine, especially the application of TCM decoction based on syndrome differentiation, can obviously reduce the main clinical symptoms of patients with COVID-19 such as fever, cough, poor appetite and diarrhea, etc., improve inflammatory reactions and immune imbalance of the body, reduce mortality and critical case conversion rate, and will not cause drug-induced liver injury.