Objective:To observe the clinical efficacy of acupuncture treatment of TCM flaccidity syndrome of spleen and stomach deficiency with the method of “directing channel and guiding qi”. MethodsSixty patients with flaccidity syndrome (polyneuropathy) of spleen and stomach deficiency were randomly divided into treatment group and control group according to the random number table method, with 30 cases in each group. The control group maintained the patients' basic medication and gave mecobalamin tablets and Vitamin B1 for oral administration three times a day; The treatment group was given acupuncture to guide channel-qi besides the routine treatment, and acupoints on the Yangming and Shaoyang channels were selected on limbs affected. The course of treatment in both groups was 4 weeks, and the changes of sensory disturbance score, nerve conduction velocity and TCM syndrome score were observed.  Results:①There were significant differences in sensory disturbance score, nerve conduction velocity and TCM syndrome score of both groups before and after treatment (P<0.05). ②After treatment, there were significant differences in sensory disturbance score, nerve conduction velocity and TCM syndrome score between the two groups (P<0.05), and the scores of the treatment group were significantly better than those of the control group.  Conclusion:The acupuncture treatment of TCM flaccidity syndrome of spleen and stomach deficiency with the method of “directing channel and guiding qi” has achieved satisfactory clinical effects, which can significantly improve the sensory disturbance score, nerve conduction velocity and TCM syndrome score, and further help to improve patients’ quality of life.