Study on classification of traditional Chinese medicine syndromes of 278 ankylosing spondylitis patients

SHEN Yi; DING Hongbai; CHENG Peng; DING Qin; HONG Mengjie; ZHANG Yuanyuan; CHENG Qingqing; BIAN Yanqin; YANG Yang; HE Dongyi; ZHU Qi

doi:10.16305/j.1007-1334.2020.07.001

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Study on classification of traditional Chinese medicine syndromes of 278 ankylosing spondylitis patients

更新时间：2022-08-31

- Study on classification of traditional Chinese medicine syndromes of 278 ankylosing spondylitis patients
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 7, Pages: 34-38(2020)
- 作者机构：
  
  1. 上海市光华中西医结合医院关节内科,上海,200052
  2. 上海中医药大学研究生院,上海,201203
  3. 上海市中医药研究院中西医结合关节炎研究所,上海,200052
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.07.001
  CLC：
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SHEN Yi, DING Hongbai, CHENG Peng, et al. Study on classification of traditional Chinese medicine syndromes of 278 ankylosing spondylitis patients. [J]. Shanghai Journal of Traditional Chinese Medicine 54(7):34-38(2020)
DOI：

SHEN Yi, DING Hongbai, CHENG Peng, et al. Study on classification of traditional Chinese medicine syndromes of 278 ankylosing spondylitis patients. [J]. Shanghai Journal of Traditional Chinese Medicine 54(7):34-38(2020) DOI： 10.16305/j.1007-1334.2020.07.001.

摘要

目的：探讨强直性脊柱炎的中医证候分类,为强直性脊柱炎证候诊断客观化提供参考依据。方法：收集278例强直性脊柱炎患者的临床四诊信息,以因子分析法提取公因子并测量症状载荷,以系统聚类分析法归纳证候群,确定强直性脊柱炎的中医证候分型。结果：通过因子分析,从强直性脊柱炎患者的临床四诊信息中提取出24个公因子；利用因子得分作为变量进行聚类分析,总结出强直性脊柱炎的4个具有代表性的中医证候群,即肾虚督寒证、肾阴虚证、湿热痹阻证和瘀血痹阻证；其中肾阴虚证可兼见阳虚和湿热,湿热痹阻证可兼有脾虚。结论：因子分析联合聚类分析结合中医基础理论归纳强直性脊柱炎的证候分型具有可行性。

Abstract

Objective:To explore the traditional Chinese medicine (TCM)syndrome types of ankylosing spondylitis(AS), and providethis article provided reference for the objective diagnosis of AS syndromes. MethodsInformations of 278 AS patients based on TCM four diagnostic methods were collected. Common factors were extracted and symptom loads were measured by factor analysis. Syndrome groups were summarized by systematic cluster analysis in order to determine the TCM syndrome types of AS. Results:24 common factors were extracted from clinical diagnostic informations of AS patients by factor analysis, and the factor scores were used as variables to cluster them.The basic TCM syndromes of AS could be divided into four categories, including nephrasthenia cold syndrome, yin-deficiency of kidney combined with yang-deficiency and dampness-heat syndrome, moist heat arthralgia spasm combined with spleen-deficiency syndrome, and stagnation of blood stasis syndrome. Conclusion:It was feasible that factor analysis combined with cluster analysis to induce AS syndromes, according to fundamental theories of TCM.

关键词

强直性脊柱炎中医证候因子分析聚类分析

Keywords

ankylosing spondylitisTCM syndromesfactor analysisclustering analysis

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