TCM treatment of coronavirus disease 2019 (COVID-19) based on “truncation and reversal” strategy was discussed. It is believed that implementing treatment measures in advance before the occurrence of corresponding syndromes is beneficial to quickly control the disease condition and truncate the disease progress. Commonly used therapeutic methods include invigorating spleen and assisting transportation, activating qi and resolving dampness, dredging fu organs and attacking the lower, cooling blood and removing blood stasis, eliminating phlegm and softening hard mass, and removing pestilential qi, etc.