Professor Wang Xixing’s clinical experience in differentiating and treating colorectal carcinoma (CRC) liver metastasis was introduced. It is believed that the fundamental pathogenesis of CRC liver metastasis is the dual deficiency of the liver and spleen and accumulation of phlegm and blood stasis. Clinically, both the root and branches of the disease are considered and the reinforcing and reducing methods are applied with regulating and harmonizing the liver and spleen as the priority and decreasing toxicity and eliminating mass as the complement. Buzhong Tiaogan (middle-tonifying and liver-regulating) decoction, a special prescription formulated to fight against cancer with the harmonizing method, has achieved great clinical effects. One case was attached for exemplification.