Objective:To design a safe, effective, simple and easy-to-learn Kangyi Qiangshen Gong (anti-epidemic and body-strengthening exercise) for clinical application to combat epidemic and strengthen body function through a retrospective analysis of 308 coronavirus disease 2019 (COVID-19) cases in Huangshi, Hubei province and with the combination of core elements and research evidence of traditional Chinese medicine (TCM) Qigong exercises. MethodsThe medical records of 308 COVID-19 cases (classified into four types:mild, moderate, severe and critical) admitted to Huangshi Hospital of Traditional Chinese Medicine from January 25,2020 to February 20,2020 were collected, and the clinical data, auxiliary examinations and treatment plans of each type were analyzed statistically. The clinical data included each patient's general information (gender, age), admission signs, degree of illness, TCM syndrome differentiation and classification, main clinical symptoms, time required for symptom improvement, residual symptoms at discharge, CT image changes of the lungs, and treatment outcomes, etc.  Results:①On admission, the total proportion of patients with moderate and mild COVID-19 reached 61%, and with the continuous recovery of severe cases, the proportion of moderate and mild cases further increased. With the aggravation of the disease from mild to critical, the average hospitalization duration of patients was continuously prolonged. ②The average age of the dead patients with critical COVID-19 was 74.1 years old, which was significantly different from that of dead patients with severe COVID-19. The age of dead patients of critical type was older (P<0.05), and before death the average hospitalization time was 9.2 days which showed a rapid progress of disease. The death cases were all patients with severe or critical COVID-19, and all of these patients were diagnosed with basic diseases before the confirmation of infection. ③The mortality rate of 308 cases in this study reached 5.19%, which was higher than the national average mortality rate of 3.83% issued by the National Center for Disease Control and Prevention. The mortality rate of critical cases was 57.14%,while the mortality rate of severe cases was 4.82%. The number of death cases of mild and moderate type was 0 and no case changed to severe type, but there were 4 death cases of critical type changing from severe type. ④The TCM syndromes of 308 patients were mainly cold-dampness stagnating in the lungs, accounting for 82%. There were also 13% of wind-heat invading the lungs syndrome and 5% of dampness-pathogen stagnating in the lungs syndrome, which were syndromes unmentioned in the Diagnosis and Treatment Protocol for COVID-19 issued by the National Health Committee. ⑤Cough, fever, chest tightness and fatigue were the most important and common symptoms. Among them, fever and diarrhea relatively had faster improvement with shorter duration and less residual symptoms at discharge. Cough, chest tightness and fatigue took longer to improve with longer persistence of symptoms at discharge. Cough, in particular, had the longest persistence at discharge compared with other symptoms and the difference was statistically significant (P<0.05). ⑥In typical cases, lung CT showed slightly reduced scope of infection foci and reduced density after treatment, but both lungs still showed ground glass-like changes suggesting that the lung function of patients would decrease in the later stage and there would be chest tightness and dyspnea. ⑦By reviewing ancient and modern literature of TCM Qigong exercises and methods, and combining the clinical characteristics of COVID-19 cases in Hubei province, TCM Qigong exercises can be respectively designed for different types of patients, ranging from moderate type, mild type to discharged ones.  Conclusion:Based on the clinical characteristics of COVID-19 cases in Hubei province, the designed Kangyi Qiangshen Gong (anti-epidemic and body-strengthening exercise) are expected to relieve the main clinical symptoms of patients with COVID-19, especially those persistent symptoms at discharge such as cough, chest tightness and fatigue, thus promoting the early recovery of patients.