Shandougen Radix Sophorae Tonkin, RST was recorded as “toxic” in the Chinese Pharmacopoeia (ChP). According to the literature, matrine and oxymatrine mainly contribute to its toxicity, and the former is more poisonous. A retrospective study was carried out on the relationship between its drying and concocting processing methods, usage and toxicity, and the idea of directly slicing fresh RST into decoction pieces was put forward and practiced. Fresh RST was quickly cleaned after harvest, the surface moisture was quickly dried up, and RST was quickly sliced into 5 mm pieces. After a complete second fast-drying, the matrine content was 0.031%. The whole process of RST played a role in controlling and reducing matrine content to lower toxicity to a certain degree.