Based on the coronavirus disease 2019 clinical symptoms,pathogenesis characteristics and syndrome differentiation and other related data in Liaoning Shenyang area and Hubei Xiangyang area,we found that the coronavirus disease 2019 was characterized by both wet and cold,determination of etiologic factors based on differentiation.It is believed that the south and the north have different emphases,the south focuses on “wet”,and the north focuses on “cold”.In the process of diagnosis and treatment in Liao Shen area,it is suggested that we should combine the regional seasonal characteristics with three categories of etiologic factors to seek common ground while reserving differences.According to the clinical manifestations of light,common,severe and critical types,we could treat them by syndromes differentiation based on different periods.Combined with the differences of individual constitution,we should explore the process of the integration of evil spirits,and argue and treat them according to constitution.Using six meridians dialectically to prevent disease transmission.At the same time,we should pay attention to prevention and reasonable care.