Objective:To observe retrospectively the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of non-critical coronavirus disease 2019 (COVID-19) patients,compared with western medicine therapy. MethodsSixty-seven patients with COVID-19 admitted to Shanghai Public Health Clinical Center were divided into the western medicine group(n=18) and the integrative medicine group(n=49) according to different therapies. The western medicine group was given oxygen therapy, antiviral and symptomatic support treatment, while patients with severe condition were given anti-inflammatory, immune regulation and intravenous immunoglobulin (IVIG) support treatment. Besides the adoption of the same treatment in the western medicine group, the integrative medicine group was also administered with Chinese patent medicine or decoction orally. The clinical data of the two groups of patients, including general conditions, relevant laboratory indexes, imaging manifestations, symptom information, and TCM pattern information (including tongue and pulse) were collected and analyzed. The clinical efficacy related indexes of the two groups of patients were observed and compared, including antipyretic time, clinical symptom score, CT improvement rate, critical case conversion rate, hospitalization time and total course of disease.  Results:①There was no significant difference in the general conditions, relevant laboratory indexes and imaging manifestations between the western medicine group and the integrative medicine group (P>0.05). ②All patients received antiviral treatment, and 27.78% were treated with antibiotics in the western medicine group,while 34.69% in the integrative medicine group. ③The main manifestations of the patients were fever (71.64%), cough/dry cough (52.24%), fatigue (47.76%), poor appetite (35.82%), sore/itching throat (31.34%), white/yellow sputum (26.87%), sweating (25.37%), diarrhea (22.39%), nasal obstruction (13.43%), and headache/dizziness (13.43%). There was no significant differences between the two groups(P>0.05).④In the integrative medicine group, 32 cases (65.31%) had damp toxin stagnating the lung pattern and 17 cases (34.69%) had heat toxin blocking the lung pattern. Patients with red or pale red tongue color, white and greasy tongue coating and slippery pulse were more commonly seen in the clinic. ⑤There were significant differences in hospitalization days and clinical symptom scores on the 6th day of admission between the integrative medicine group and the western medicine group (P<0.05). However, there was no significant difference in the total course of disease, antipyretic time and CT improvement rate on the 6th day of admission between the two groups (P>0.05). ⑥During the observation period, there was no case transforming to the critical condition in both groups.  Conclusion:The integrated Chinese and western medicine treatment has shown great advantages in shortening the hospitalization time and improving the main clinical symptoms of patients with COVID-19 such as fever, cough and fatigue.