Objective:To investigate the effect mechanism Bushen Jiangzhi recipe on atherosclerosis (AS) in ApoE-/- mice by regulating PPARγ-LXRα-ABCA1 pathway. MethodsApoE-/- mice with high-fat diet were randomly divided into three groups: ApoE-/- mice + high-fat diet group (model group), ApoE-/- mice + high-fat diet + Bushen Jiangzhi recipe group (Bushen group), and ApoE-/- mice + high-fat diet + Atorvastatin group (statin group). Male C57BL/6 mice of the same age and strain were used as normal control group (normal group) fed with common diet with 25 mice in each group. Each group was given corresponding intervention for 12 weeks. HE and Oil Red O staining were performed to detect pathological morphology and lipid accumulation of mouse aortic sinus and liver tissues respectively, and Filipin staining was performed to detect free cholesterol in mouse aortic sinus. Serum lipid levels (TC, TG, LDL-C, HDL-C) in peripheral blood of mice were detected by ELISA; The expression of PPARγ, LXRα and ABCA1 in aorta and liver tissues of mice was analyzed by Western blot.  Results:ApoE-/- mice fed with high-fat diet showed typical AS lesions, large area of AS plaque and red-stained lipid were seen in aortic sinus, and free cholesterol increased. Hepatocyte structure disorder and red-stained lipid accumulation can be seen in the liver tissue. The content of TC and LDL-C in serum increased while that of HDL-C decreased. The protein expression levels of PPARγ, LXRα and ABCA1 in aorta and liver tissues decreased. Compared with the model group, the area of AS plaque, red stained lipid and free cholesterol in aortic sinus of mice in Bushen group decreased. after intervention by Bushen Jiangzhi recipe. The structure of liver cells in liver tissue was mostly clearly visible, and red stained lipid reduced. The content of serum TC and LDL-C decreased. The protein expression levels of PPARγ, LXRα and ABCA1 in aorta and liver tissues were up-regulated after intervention by Bushen Jiangzhi recipe (P<0.05, P<0.01, P<0.001).  Conclusion:Bushen Jiangzhi recipe may effectively intervene the treatment of AS by regulating PPARγ-LXRα-ABCA1 pathway.