Objective:To explore the therapeutic effect of GnRHa combined with Bushen Huayu Decoction coloclysis and Yigeng Decoction orally in treating patients with endometriosis (EMT) after laparoscopic surgery. MethodsNinety patients with EMT after laparoscopic surgery were enrolled and randomly divided into four groups, including 22 cases in GnRHa group, 20 cases in GnRHa + coloclysis group, 26 cases in GnRHa + Yigeng Decoction group, and 22 cases in GnRHa + Chinese medicine double therapy group, according to hierarchical method. The patients in the GnRHa group were given subcutaneous injection of enantone, the patients in the GnRHa + coloclysis group were given subcutaneous injection of enantone combined with Bushen Huayu Decoction coloclysis, the patients in the GnRHa + Yigeng Decoction group were given subcutaneous injection of enantone combined with Yigeng Decoction orally, and the patients in the GnRHa + Chinese medicine double therapy group were given subcutaneous injection of enantone combined with Bushen Huayu Decoction coloclysis and Yigeng Decoction orally. Twenty-eight days were a treatment course and all the patients were treated for 3 courses. Follow-up for 1 year after treatment, the dysmenorrhea scores and Chinese medical syndrome scores of all the groups were compared before surgery, 6 months and 1 year after treatment after surgery; the levels of serum cancer antigen (CA) 125, follicle stimulating hormone (FSH) and estradiol (E,2,) were detected, and the improvement of postmenopausal symptoms were evaluated by modified Kupperman score (K score) before surgery and after treatment after surgery.  Results:①Six months and 1 year after treatment, the Chinese medical syndrome scores of all groups were obviously decreased compared with before surgery (P,<,0.05); 1 year after treatment, the Chinese medical syndrome score of the GnRHa group was significantly increased compared with 6 months after treatment (P,<,0.05). Six months and 1 year after treatment, the Chinese medical syndrome scores of the GnRHa + Chinese medicine double therapy group and GnRHa + coloclysis group were lower than those of the GnRHa group and GnRHa + Yigeng Decoction group (P,<,0.05). ②Six months and 1 year after treatment, the dysmenorrhea scores of all groups were obviously decreased compared with before surgery (P,<,0.05); 1 year after treatment, the dysmenorrhea scores of all groups were increased compared with 6 months after treatment (P,<,0.05). Six months and 1 year after treatment, the dysmenorrhea scores of the GnRHa + Chinese medicine double therapy group and GnRHa + coloclysis group were lower than those of the GnRHa group and GnRHa + Yigeng Decoction group (P,<,0.05). ③After treatment, the levels of FSH, E,2, and CA125 of all the groups were obviously decreased compared with before surgery (P,<,0.05). After treatment, there were no sigificant statistical differences on the level of FSH among all the groups (P,>,0.05); the levels of E,2, in the GnRHa group and GnRHa + coloclysis group were lower than those in the GnRHa + Yigeng Decoction group and GnRHa + Chinese medicine double therapy group (P,<,0.05); the levels of CA125 in the GnRHa + Chinese medicine double therapy group and GnRHa + coloclysis group were lower than those in the GnRHa group and GnRHa + Yigeng Decoction group (P,<,0.05). ④After treatment, the K scores of all the groups were obviously increased (P,<,0.05), and the K scores of the GnRHa group and GnRHa + coloclysis group were higher than those of the GnRHa + Yigeng Decoction group and GnRHa + Chinese medicine double therapy group (P,<,0.05).  Conclusion:All the four therapeutic regimens can improve the Chinese medical syndrome and dysmenorrhea symptom, and decrease the level of CA125 in patients with EMT; GnRHa combined with Bushen Huayu Decoction coloclysis can better improve the Chinese medical syndrome and dysmenorrhea scores, and GnRHa combined with Yigeng Decoction orally can better improve the postmenopausal symptoms which were induced by the use of GnRHa; GnRHa combined with Bushen Huayu Decoction coloclysis and Yigeng Decoction orally can better improve the clinical symptoms of EMT, and relieve the postmenopausal symptoms, which is worthy popularization and application in clinic.