Clinical study on berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes

YANG Xin; LIU Zhimin; YANG Hongjie

doi:10.16305/j.1007-1334.2020.03.017

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Clinical study on berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes

更新时间：2022-08-31

- Clinical study on berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 3, Pages: 59-62(2020)
- 作者机构：
  
  1. 南华大学衡阳医学院,湖南,衡阳,421001
  2. 上海市普陀区人民医院内分泌科,上海,200060
  3. 海军军医大学附属长征医院内分泌科,上海,200000
  4. 上海中医药大学附属岳阳中西医结合医院内分泌科,上海,200437
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.03.017
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YANG Xin, LIU Zhimin, YANG Hongjie. Clinical study on berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes. [J]. Shanghai Journal of Traditional Chinese Medicine 54(3):59-62(2020)
DOI：

YANG Xin, LIU Zhimin, YANG Hongjie. Clinical study on berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes. [J]. Shanghai Journal of Traditional Chinese Medicine 54(3):59-62(2020) DOI： 10.16305/j.1007-1334.2020.03.017.

摘要

目的：观察盐酸小檗碱片联合二甲双胍治疗初发2型糖尿病的临床疗效。方法：将192例初发2型糖尿病患者随机分为治疗组和对照组,每组96例；对照组予二甲双胍治疗,治疗组在对照组基础上加盐酸小檗碱片治疗。两组疗程均为6个月,观察两组血糖(FBG、2 hPPG、HbA1c)、血脂(TC、LDL-C)、BMI、氧化应激产物(8-OHdG、MDA、SOD)、免疫细胞因子(TNF-α、IL-6)的变化情况,并分析HbA1c与氧化应激产物(8-OHdG、MDA、SOD)、免疫细胞因子(TNF-α、IL-6)之间的相关关系。结果：两组治疗后,FBG、2 hPPG、HbA1c、TC、LDL-C、BMI、8-OHdG、MDA、TNF-α、IL-6均较治疗前明显下降(P<0.05),SOD明显升高(P<0.05)；组间治疗后比较,治疗组各项指标均优于对照组(P<0.05),且8-OHdG与HbA1c呈正相关。结论：盐酸小檗碱片联合二甲双胍能有效降低初发2型糖尿病患者的血糖、血脂、体质量,减轻患者氧化应激及炎症反应；8-OHdG有可能成为2型糖尿病治疗预后的评价指标。

Abstract

Objective:To observe the clinical effect of berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes. MethodsA total of 192 patients with primary type 2 diabetes were randomly divided into treatment group and control group, 96 cases in each group; the control group was treated with metformin, and the treatment group was treated with berberine hydrochloride tablets and metformin. The course of treatment in both groups was 6 months. The changes of blood glucose (FBG, 2 hPPG, HbA1c), blood lipid (TC, LDL-C), BMI, oxidative stress products (8-OHdG, MDA, SOD), and immune cytokines (TNF-α, IL-6) were observed and the correlation between HbA1c and oxidative stress products (8-OHdG, MDA, SOD), immune cytokines (TNF-α, IL-6) was analyzed. Results:After treatment, the levels of FBG, 2 hPPG, HbA1c, TC, LDL-C, BMI, 8-OHdG, MDA, TNF-α, IL-6 significantly decreased (P<0.05) and the level of SOD significantly increased (P<0.05) in both groups; after treatment, all indexes in the treatment group improved more significantly than those in the control group (P<0.05), and 8-OHdG was positively correlated with HbA1c. Conclusion:Berberine hydrochloride tablets combined with metformin can effectively reduce the blood glucose, blood lipid, body mass, oxidative stress and inflammatory response in patients with primary type 2 diabetes, and 8-OHdG may be an evaluation index for the prognosis of type 2 diabetes mellitus.

关键词

初发2型糖尿病盐酸小檗碱片黄连素氧化应激细胞因子临床研究

Keywords

primary type 2 diabetes mellitusberberine hydrochloride tabletsberberineoxidative stressimmune cytokineclinical study

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