The Guideline on the Diagnosis and Treatment of Hepatic Fibrosis With Integrated Chinese and Western Medicine (2019 Edition) (new guideline) was issued by Professional Committee of Liver Disease of Chinese Society of Integrated Traditional Chinese and Western Medicine. It is a renewed edition of 2016 Edition (old guideline). The content is more closed to the clinical in the new guideline. There are 16 recommended suggestions with higher degree evidences in the new edition. In the new guideline, a section of pathological mechanism of hepatic fibrosis is added; the advantage of noninvasive diagnosis methodology in the section of diagnosis is confirmed; it is highlighted that the principle of therapy for the treatment of pathogen and for hepatic fibrosis is regarded both as equally important and several Chinese patent medicines and medicinal formulae are majorly recommended in the section of therapy; the main thinking which is in the research field of fibrosis is introduced about regression of hepatic fibrosis or liver cirrhosis in evaluation of therapeutic effect; the suggestion is added for treatment course, drug withdrawal and follow-up of anti-hepatic fibrosis; and finally four problems needed paing attention to and improved are presented.