Objective:To observe the clinical efficacy of Shao’s yang deficiency asthma patch combined with low-dose salmeterol fluticasone in patients with chronic persistent bronchial asthma of kidney-yang deficiency pattern. MethodsA total of 65 patients with chronic duration of bronchial asthma of kidney-yang deficiency pattern were randomly divided into the treatment group (33 cases) and the control group (32 cases). The control group was treated with salmeterol fluticasone powder inhalation (Seretide), and the treatment group was treated with Shao’s yang deficiency asthma patch and low-dose Seretide. The course of treatment in both groups was 42 days. Cases were followed for 6 months to observe the clinical effect. The changes in TCM syndrome score, asthma control level (ACT) score, lung function, and exhaled nitric oxide (FeNO) level were compared.  Results:① The total effective rate in the treatment group was 87.9%, and the total effective rate in the control group was 81.3%. Comparing the clinical efficacy of the two groups, the treatment group showed better clinical efficacy than the control group (P<0.05). ② After treatment, follow-up for 3 months, and follow-up for 6 months, the total scores of TCM syndromes and secondary symptoms in both groups decreased compared with those before treatment (P<0.05). After treatment and follow-up for 3 months, the total scores of TCM syndromes and secondary symptoms in the treatment group were lower than those in the control group (P<0.05). There was no significant difference in the total scores of TCM syndromes between two groups after 6-month follow-up (P>0.05), the score of secondary symptoms in the treatment group was lower than that in the control group (P<0.05). ③ After treatment, follow-up for 3 months, and follow-up for 6 months, the ACT scores of the two groups were higher than those before treatment (P<0.05); there was no significant difference in ACT scores between groups at each observation time point (P>0.05). ④ The differences in FEV1, FeNO levels, and FEV1 / FVC values between the two groups were statistically significant (P<0.05) when compared before the treatment and after 6-month follow-up; Compared after 6-month follow-up between groups, the differences in FEV1, FeNO levels, and FEV1 / FVC values were not statistically significant (P>0.05).  Conclusion:Shao’s yang deficiency asthma patch combined with low-dose Seretide showed satisfactory effects in the treatment of patients with chronic duration of persistent bronchial asthma of kidney yang deficiency pattern. Compared with conventional dosage of Seretide, it can better alleviate the clinical symptoms of patients by simple operation, which is worthy of clinical promotion.