From the discussion of the “Yangming’s cold and warm” of the Records of Tradition Chinese and Western Medicine in Combination written by Zhang Xichun and combined with the medical cases, this paper analyzes Zhang’s thought of unification of febrile disease and warm disease. In the opinion of the “In the febrile disease and warm disease,the beginning is different but the end is the same”,it is suggested that the methods of six-channel differentiation of febrile diseases should be used to treat warm diseases,and the “febrile disease and warm disease” concept should be paid attention to in the course of treating the disease. In the meantime, Zhang’s self-created prescription for febrile diseases or warm diseases and detailed records of clinical medical cases in the book are also analyzed to prove the theory.