This paper introduces Professor Shi Yumin’s experience in the treatment of chronic idiopathic neutropenia of children. It is believed that the disease is based on the deficiency of the spleen and kidney, and syndrome of intermingled deficiency and excess. In the treatment of the disease, attention should be paid to both root causes and symptom causes, and the disease should be treated by stages. At the stage of infection, the main treatment method is dispelling pathogenic factors and treating symptom causes with light, clearing and dispersing medical herbs, followed by the herbs with the function of strengthening healthy qi; at the stable stage, the main treatment method is treating the root causes and reinforcing deficiency, namely invigorating the spleen and tonifying the kidney, invigorating the lung and replenishing defensive qi, replenishing qi and supplementing blood, promoting blood circulation and generating blood. The disease is often treated with modified Yigong powder, Shiquan Dabu decoction combined with Zuogui pill. And one proven case is presented.