This paper explores the clinical experience of Professor Shi Guochen in the treatment of nervous system diseases by acupuncture combined with medicine based on Fenxiao Zouxie theory. The origins and definitions of Fenxiao Zouxie theory and the idea of acupuncture combined with medicine based on Fenxiao Zouxie theory are systematically analyzed. The basis and its application of Fenxiao Zouxie theory in the treatment of nervous system diseases are explained. The clinical effect of this method in the treatment of damp-heat type nervous system diseases is given with a case report.