Observation on the therapeutic effect of Kangmin Zhike decoction combined with Kechuanning acupoint application on children with cough variant asthma of wind cold type
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Observation on the therapeutic effect of Kangmin Zhike decoction combined with Kechuanning acupoint application on children with cough variant asthma of wind cold type
Shanghai Journal of Traditional Chinese MedicineVol. 53, Issue 12, Pages: 56-60(2019)
YE Lu, TANG Bixin, GUO Yanfang, et al. Observation on the therapeutic effect of Kangmin Zhike decoction combined with Kechuanning acupoint application on children with cough variant asthma of wind cold type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(12):56-60(2019)
DOI:
YE Lu, TANG Bixin, GUO Yanfang, et al. Observation on the therapeutic effect of Kangmin Zhike decoction combined with Kechuanning acupoint application on children with cough variant asthma of wind cold type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(12):56-60(2019) DOI: 10.16305/j.1007-1334.2019.12.016.
Observation on the therapeutic effect of Kangmin Zhike decoction combined with Kechuanning acupoint application on children with cough variant asthma of wind cold type
Objective:To observe the clinical effect of Kangmin Zhike (anti-allergy and cough-relieving) decoction combined with Kechuanning (cough-asthma-calming) acupoint application on children with cough variant asthma (CVA) due to wind-cold. MethodsRandomly divide 90 children with CVA into the control group, the decoction group and the combination group with 30 cases each. The control group was given montelukast sodium chewable tablets, the decoction group was given Kangmin Zhike (anti-allergy and cough-relieving) decoction orally, and the combination group was given Kangmin Zhike (anti-allergy and cough-relieving) decoction and Kechuanning (cough-asthma-calming) acupoint application. All the three groups were treated for 8 weeks. The scores of TCM patterns, the changes of percentage of forced expiratory volume in 1 second (FEV1%), percentage of predicted peak expiratory flow (PEF%) and fractional exhaled nitric oxide (FeNO) concentration were observed and compared, and the recurrence was also observed 2 months after the treatment. Results:①The differences of TCM pattern scores in each group before and after treatment were significant (P<0.01); according to the comparison of difference values calculated based on TCM pattern scores before and after treatment, the decoction group showed better improvement than the control group (P<0.05) and the improvement in the combination group was even more significant than that in the control group (P<0.01) and that in the control group (P<0.01) and that in the decoction group (P<0.05). ②The FEV1% and PEF% of the three groups all increased after treatment (P<0.05), and the increase of FEV1% and PEF% was especially significant in the combination group (P<0.01); Based on the comparison of FEV1% and PEF% among three groups after treatment, the improvement in the decoction group was better than that in the control group (P<0.05) and the improvement in the combination group was better than that in the control group (P<0.01) and that in the decoction group (P<0.05). ③The levels of FeNO of the three groups all decreased when compared before and after treatment (P<0.05), and the decrease of FeNO level was more significant in the combination group (P<0.01); According to the comparison of FeNO levels among groups after treatment, the decoction group had a lower FeNO level than the control group (P<0.05), and the combination group had an even lower FeNO level than the control group (P<0.01) and the decoction group (P<0.05). ④The recurrence rates of the control group, decoction group and combination group were 32.00%, 18.52% and 7.14% respectively, and the differences were statistically significant (P<0.01). ⑤During the trial, no serious adverse reactions were found in each group, and no abnormality was found in blood routine test, urination and stool routine test, and liver and kidney function test. Conclusion:The combination of Kangmin Zhike (anti-allergy and cough-relieving) decoction and Kechuanning (cough-asthma-calming) acupoint application can significantly improve the symptoms, pulmonary function and airway inflammation of children with wind-cold type CVA, and reduce the recurrence rate.
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Department of Traditional Chinese Medicine, Children’s Hospital of Fudan University
Institute of Pediatrics, Shanghai Academy of Traditional Chinese Medicine
Department of Pediatrics, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Department of Respiratory, Fudan University of Children’s Hospital
Department of Infectious Disease, Fudan University of Children’s Hospital