Yanghe Yifei decoction combined with Western medicine in treatment of 40 patients with pulmonary fibrosis of lung-kidney yang deficiency type

LIU Yang; YU Pan; HAN Jinhua; SUN Fengyun; ZHENG Caixia

doi:10.16305/j.1007-1334.2019.11.011

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Yanghe Yifei decoction combined with Western medicine in treatment of 40 patients with pulmonary fibrosis of lung-kidney yang deficiency type

更新时间：2022-08-31

- Yanghe Yifei decoction combined with Western medicine in treatment of 40 patients with pulmonary fibrosis of lung-kidney yang deficiency type
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 11, Pages: 53-56(2019)
- 作者机构：
  
  1. 安徽省淮北市中医医院肺病科,安徽,淮北,235000
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.11.011
  CLC：
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LIU Yang, YU Pan, HAN Jinhua, et al. Yanghe Yifei decoction combined with Western medicine in treatment of 40 patients with pulmonary fibrosis of lung-kidney yang deficiency type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(11):53-56(2019)
DOI：

LIU Yang, YU Pan, HAN Jinhua, et al. Yanghe Yifei decoction combined with Western medicine in treatment of 40 patients with pulmonary fibrosis of lung-kidney yang deficiency type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(11):53-56(2019) DOI： 10.16305/j.1007-1334.2019.11.011.

摘要

目的：观察阳和益肺汤联合西药治疗肺肾阳虚型肺纤维化的临床疗效。方法：将80例肺肾阳虚型肺纤维化患者随机分为治疗组、对照组,每组40例。对照组予吸氧及口服甲泼尼龙、乙酰半胱氨酸治疗,治疗组在对照组治疗措施基础上加用阳和益肺汤。两组疗程均为3个月,观察临床疗效,比较症状体征积分、高分辨率CT(HRCT)评分、肺功能及血清转化生长因子-β1(TGF-β1)、γ干扰素(IFN-γ)、白介素-17(IL-17)水平的变化情况。结果：①治疗组、对照组总有效率分别为90.0%、80.0%；治疗组临床疗效优于对照组(P＜0.05)。②治疗前后组内比较,两组喘息、咳嗽、咯痰、Velcro啰音、HRCT评分差异有统计学意义(P＜0.05)；组间治疗后比较,喘息、咳嗽、HRCT 评分差异有统计学意义(P＜0.05)。③治疗前后组内比较,治疗组肺功能指标中肺活量(VC)有改善(P＜0.05)；组间治疗后比较,VC值差异有统计学意义(P<0.05)。④治疗前后组内比较,两组血清IFN-γ水平升高,血清TGF-β1、IL-17水平降低(P＜0.05)；组间治疗后比较,治疗组血清IFN-γ水平高于对照组(P＜0.05)。结论：阳和益肺汤联合西药治疗肺肾阳虚型肺纤维化疗效满意,较单纯采用西药能更好地改善患者的临床症状,其机制可能与上调血清IFN-γ的表达水平有关。

Abstract

Objective:To observe the clinical efficacy of Yanghe Yifei decoction combined with Western medicine in the treatment of pulmonary fibrosis of the lung-kidney yang deficiency type. MethodsEighty patients with pulmonary fibrosis due to deficiency of lung and kidney yang were randomly assigned into treatment group and control group, 40 patients in each group. The control group was given oxygen, oral methylprednisolone and acetylcysteine, while the treatment group was given Yanghe Yifei decoction in addition. The two groups were treated for 3 months. The clinical efficacy was observed and the changes in symptom and sign score, HRCT score, lung function and serum levels of transforming growth factor-β1 (TGF-β1), interferon-γ (IFN-γ) and interleukin-17 (IL-17) were compared. Results:①The total effective rate was 90.0% and 80.0% in the treatment group and the control group, respectively. The clinical efficacy was superior in the treatment group to that in the control group (P<0.05). ②There were significant differences in asthma, cough, expectoration, Velcro rale and HRCT scores in both groups before and after treatment (P<0.05); there were significant differences in asthma, cough and HRCT scores between the two groups after treatment (P<0.05). ③Vital capacity (VC) was improved in the treatment group after treatment (P<0.05); there was significant difference in the level of VC between the two groups after treatment (P<0.05). ④The serum level of IFN-γ increased and the serum levels of TGF-beta 1 and IL-17 decreased in both groups after treatment (P<0.05); after treatment, the serum level of IFN-γ was higher in the treatment group than in the control group (P<0.05). Conclusion:Yanghe Yifei decoction combined with Western medicine shows satisfactory effect in treatment of pulmonary fibrosis of the lung-kidney yang deficiency type. It improves the clinical symptoms better than Western medicine alone and its mechanism of action may be related to up-regulation of the expression level of serum IFN-γ.

关键词

肺纤维化肺肾阳虚中西医结合疗法阳和益肺汤

Keywords

pulmonary fibrosislung-kidney yang deficiencyintegrated Chinese and Western medicine therapyYanghe Yifei decoction

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