Zha Weimin is very good at treating difficult miscellaneous diseases,such as chronic gastritis complicated with oral lichen planus treated with the methods of soothing the liver and harmonizing the stomach and clearing away heat,invigorating the spleen and supplementing qi and nourishing yin; Henoch-Schonlein purpura nephritis complicated with chronic gastritis treated with the methods of invigorating qi and nourishing yin,dredging the collaterals and detoxify ; meniscus injury complicated with fasciitis and tennis elbow treated with the methods of nourishing the liver and kidney,invigorating the spleen to eliminate dampness,dispel the wind and dredging the collaterals; systemic lupus erythematosus complicated with postherpetic neuralgia treated with the methods of clearing away heat and promoting diuresis,activating blood circulation and detoxify,strengthening healthy qi to consolidate body resistance . Four cases of difficult miscellaneous diseases treated by Zha Weimin with the methods of treating different diseases with the same therapy were analyzed.