Molecular mechanisms of cardiac hypertrophy and progress in intervention with traditional Chinese medicine

ZHANG Jianwei; LIU Li

doi:10.16305/j.1007-1334.2019.10.023

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Molecular mechanisms of cardiac hypertrophy and progress in intervention with traditional Chinese medicine

更新时间：2022-08-31

- Molecular mechanisms of cardiac hypertrophy and progress in intervention with traditional Chinese medicine
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 10, Pages: 100-105(2019)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院,上海,200021
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.10.023
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ZHANG Jianwei, LIU Li. Molecular mechanisms of cardiac hypertrophy and progress in intervention with traditional Chinese medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 53(10):100-105(2019)
DOI：

ZHANG Jianwei, LIU Li. Molecular mechanisms of cardiac hypertrophy and progress in intervention with traditional Chinese medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 53(10):100-105(2019) DOI： 10.16305/j.1007-1334.2019.10.023.

摘要

综述心肌肥大的分子机制和中药防治心肌肥大的最新研究进展。心肌肥大是心力衰竭的主要风险因素,是由多种细胞因子和/或信号通路(如钙信号传导、AMPK、TLR4/NF-κB、MAPK、PI3K/AKT以及氧化应激相关等)失调引起的；黄芪甲苷、天麻素、人参皂苷以及蜂胶、积雪草等可通过调节相关通路阻止或逆转病理性肥大,从而避免发展为心力衰竭。

Abstract

The molecular mechanisms involved in cardiac hypertrophy and the latest research progress in preventing and treating the disease with traditional chinese medicine (TCM) are reviewed. Cardiac hypertrophy is a major risk factor for heart failure, which may result from the dysregulation of multiple cellular factors and/or signaling pathways, such as the calcium signaling, AMPK, TLR4/NF-κB, MAPK, PI3K/Akt and oxidative stress-related signaling pathways. Pathological hypertrophy can be prevented or reversed by astragaloside A, gastrodin, ginsenoside, propolis and asiatic pennywort herb by regulating related pathways, thereby avoiding progression to heart failure.

关键词

心肌肥大中药信号通路综述

Keywords

cardiac hypertrophyChinese medicinesignaling pathwayreview

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