Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention

SUN Jie; CHENG Lihong; MIN Youjiang

doi:10.16305/j.1007-1334.2019.09.023

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Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention

更新时间：2022-08-31

- Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 9, Pages: 90-94(2019)
- 作者机构：
  
  1. 江西中医药大学针灸推拿学院,江西,南昌,330000
  2. 上海市第八人民医院中医科,上海,200235
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.09.023
  CLC：
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SUN Jie, CHENG Lihong, MIN Youjiang. Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention. [J]. Shanghai Journal of Traditional Chinese Medicine 53(9):90-94(2019)
DOI：

SUN Jie, CHENG Lihong, MIN Youjiang. Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention. [J]. Shanghai Journal of Traditional Chinese Medicine 53(9):90-94(2019) DOI： 10.16305/j.1007-1334.2019.09.023.

摘要

综述11β-羟类固醇脱氢酶Ⅰ型(11β-HSD1)在代谢综合征中的作用及药物干预研究概况。11β-HSD1在脂肪细胞中通过c-Jun氨基末端激酶(JNK)活化介导胰岛素抵抗；己糖-6-磷酸脱氢酶可活化11β-HSD1,引起胰岛素抵抗；11β-HSD1对海马(杏仁核)-HPA轴有双向调节作用。研究发现,某些中药单体及复方可通过11β-HSD1治疗代谢综合征。

Abstract

This paper reviews the role and research of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) in metabolic syndrome. 11β-HSD1 mediates insulin resistance in adipocytes via c-Jun N-terminal kinase (JNK) activation; hexose-6-phosphate dehydrogenase activates 11β-HSD1,causing insulin resistance; 11β-HSD1 on hippocampus (amygdala) -the HPA axis has a two-way adjustment. It has been found that some of Chinese medicine monomers and compounds can treat metabolic syndrome by regulating the level of 11β-HSD1.

关键词

代谢综合征11β-羟类固醇脱氢酶Ⅰ型11β-羟类固醇脱氢酶Ⅰ型抑制剂中药综述

Keywords

metabolic syndrome11β-hydroxysteroid dehydrogenase I11 β-hydroxysteroid dehydrogenase type I inhibitorChinese herbsreview

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