Effect of Liuwei Dihuang Pill on glucose metabolism in insulin-resistant mice and its relationship with osteocalcin

TAO Lewei; LU Hao

doi:10.16305/j.1007-1334.2019.08.019

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Effect of Liuwei Dihuang Pill on glucose metabolism in insulin-resistant mice and its relationship with osteocalcin

更新时间：2022-08-31

- Effect of Liuwei Dihuang Pill on glucose metabolism in insulin-resistant mice and its relationship with osteocalcin
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 8, Pages: 77-80(2019)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院内分泌科,上海,20203
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.08.019
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TAO Lewei, LU Hao. Effect of Liuwei Dihuang Pill on glucose metabolism in insulin-resistant mice and its relationship with osteocalcin. [J]. Shanghai Journal of Traditional Chinese Medicine 53(8):77-80(2019)
DOI：

TAO Lewei, LU Hao. Effect of Liuwei Dihuang Pill on glucose metabolism in insulin-resistant mice and its relationship with osteocalcin. [J]. Shanghai Journal of Traditional Chinese Medicine 53(8):77-80(2019) DOI： 10.16305/j.1007-1334.2019.08.019.

摘要

目的：探讨六味地黄丸对胰岛素抵抗小鼠糖代谢的影响及其与骨钙素的关系。方法：将高脂饮食诱导的胰岛素抵抗模型小鼠,分为六味地黄丸小剂量组、中剂量组、大剂量组、西药组(吡格列酮),模型组,加上正常组共6组。给予相应药物干预8周后,检测空腹血糖(FBG)、胰岛素(Fins)和骨钙素。结果：与模型组比较,六味地黄丸小剂量组能够明显改善胰岛素抵抗小鼠的FBG(P<0.01)；六味地黄丸小剂量组和大剂量组的Fins均明显降低(P<0.01,P<0.05)；六味地黄丸各剂量组均能明显升高胰岛素抵抗小鼠的未羧化骨钙素(P<0.01,P<0.05),同时小剂量组能明显升高未羧化骨钙素/羧化骨钙素。相关性分析显示,未羧化骨钙素与FBG存在负相关(P<0.05)；未羧化骨钙素/羧化骨钙素与FBG和Fins均存在负相关(P<0.01,P<0.05)。结论：六味地黄丸能明显改善胰岛素抵抗小鼠的FBG和Fins；相比于未羧化骨钙素,未羧化骨钙素/羧化骨钙素能更好地解释六味地黄丸对糖代谢的改善作用。

Abstract

Objective:To investigate the effect of Liuwei Dihuang Pill on glucose metabolism in insulin-resistant mice and its relationship with osteocalcin. MethodsMice with insulin resistance induced by high-fat diet were divided into low-, middle- and high-dose groups of Liuwei Dihuang Pill, Western medicine group (pioglitazone), model group and normal group. After 8 weeks of intervention, fasting blood glucose (FBG), fasting insulin (Fins) and osteocalcin were detected. Results:Compared with the model group, FBG was improved significantly in insulin-resistant mice in the low-dose group (P<0.01); Fins was significantly lower in the low- and high-dose groups of Liuwei Dihuang Pill (P<0.01, P<0.05); uncarboxylated osteocalcin was increased significantly in insulin-resistant mice in the groups of Liuwei Dihuang Pill (P<0.01, P<0.05) and the ratio of uncarboxylated to carboxylated osteocalcin increased significantly in the low-dose group of Liuwei Dihuang Pill. Correlation analysis showed a negative correlation between uncarboxylated osteocalcin and FBG (P<0.05); the ratio of uncarboxylated to carboxylated osteocalcin was negatively correlated with FBG (P<0.01) and Fins (P<0.05). Conclusion:FBG and Fins are significantly improved in insulin-resistant mice in the low-dose group of Liuwei Dihuang Pill. Compared with uncarboxylated osteocalcin, the ratio of uncarboxylated to carboxylated osteocalcin better explains the improvement of glucose metabolism by Liuwei Dihuang Pill.

关键词

六味地黄丸胰岛素抵抗骨钙素糖代谢小鼠

Keywords

Liuwei Dihuang Pillinsulin resistanceosteocalcinglucose metabolismmice

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