Objective:To investigate the effects of modified Qingying Decoction on the expression of TNF-α and IL-4 in dorsal skin of rats with acute eczema. MethodsSixty SD rats were randomly divided into 6 groups, 10 rats in each group:loratadine group, high-, middle-, and low-dose Qingying Decoction groups, model group and normal group. No modelling treatment was performed in the normal group. Rats in the other groups were modeled by applying 2,4-Dinitrochlorobenzene (DNCB) reagent on the right back of rats’ skin, and then modified Qingying Decoction, loratadine solution, and 0.9% NaCl solution were given to the successfully modelled rats by gastric gavage. After treatment, the severity of eczema in the experimental groups was evaluated by scoring. Skin weight was measured and compared after treatment. The content of TNF-α and IL-4 in skin tissue of the right back of rats was determined by immunohistochemistry (SP method).  Results:①Compared with the model group, the scores of severity of eczema were reduced significantly in the middle- and low-dose Qingying Decoction groups (P<0.05), especially in the high-dose group (P<0.01), suggesting that Qingying Decoction could significantly improve the symptoms of skin erosion, edema and erythema in rats caused by DNCB. ②Compared with the model group, the degree of swelling was reduced significantly in the loratadine group and the Qingying Decoction groups (P<0.01); it was reduced significantly in the middle- and high-dose Qingying Decoction groups compared with the low-dose group (P<0.05); it was reduced significantly in the high-dose Qingying Decoction group compared with the middle-dose group (P<0.05); it was reduced significantly in the high-dose Qingying Decoction group compared with the loratadine group (P<0.05). ③Compared with the model group, the content of TNF-α and IL-4 in the affected skin tissue decreased significantly in the loratadine group and the Qingying Decoction groups (P<0.01); it decreased significantly in the high-dose Qingying Decoction group compared with the loratadine group (P<0.05).  Conclusion:Modified Qingying Decoction can significantly improve the symptoms of local exudation, erosion, erythema and swelling in rats with acute eczema and it may exert the therapeutic effects by regulating the levels of TNF-α and IL-4.