Clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease of spleen-and-kidney qi deficiency type and its effect on inflammatory cytokines

WANG Yixi; CEN Jie; XU Bing

doi:10.16305/j.1007-1334.2019.07.012

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Clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease of spleen-and-kidney qi deficiency type and its effect on inflammatory cytokines

更新时间：2022-08-31

- Clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease of spleen-and-kidney qi deficiency type and its effect on inflammatory cytokines
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 7, Pages: 44-47(2019)
- 作者机构：
  
  1. 上海中医药大学附属岳阳中西医结合医院肾内科,上海,200437
  2. 上海中医药大学附属岳阳中西医结合医院闵行分院肾内科,上海,200241
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.07.012
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WANG Yixi, CEN Jie, XU Bing. Clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease of spleen-and-kidney qi deficiency type and its effect on inflammatory cytokines. [J]. Shanghai Journal of Traditional Chinese Medicine 53(7):44-47(2019)
DOI：

WANG Yixi, CEN Jie, XU Bing. Clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease of spleen-and-kidney qi deficiency type and its effect on inflammatory cytokines. [J]. Shanghai Journal of Traditional Chinese Medicine 53(7):44-47(2019) DOI： 10.16305/j.1007-1334.2019.07.012.

摘要

目的：评价芪蓣清化汤治疗脾肾气虚型慢性肾脏病蛋白尿的临床疗效及其对炎症细胞因子的影响。方法：将72例脾肾气虚型慢性肾脏病蛋白尿患者随机分为治疗组和对照组,每组36例。两组均予西医常规治疗,治疗组同时予芪蓣清化汤,对照组予肾炎康复片。两组疗程均为6个月,观察临床疗效以及中医证候积分、24 h尿蛋白定量、肾功能、血清白蛋白、血脂、炎症细胞因子(hs-CRP、TNF-α、IL-6)水平的变化情况。结果：①治疗组、对照组总有效率分别为77.8%、52.8%,治疗组临床疗效优于对照组(P<0.05)。②治疗前后组内比较,两组浮肿、纳少脘胀积分及证候总积分均降低(P<0.05),治疗组腰脊酸痛、疲倦乏力积分亦降低(P<0.05)；组间治疗后比较,治疗组腰脊酸痛、疲倦乏力积分及证候总积分明显低于对照组(P<0.05)。③治疗前后组内比较,两组24 hUPro均显著降低(P<0.05)；治疗后组间比较,治疗组24 hUPro、SCr、eGFR水平均较对照组改善(P<0.05)。④=4\*GB3治疗前后组内比较,两组hs-CRP、TNF-α、IL-6水平均降低(P<0.05)；治疗后组间比较,治疗组hs-CRP、TNF-α、IL-6水平均低于对照组(P<0.05)。结论：芪蓣清化汤可有效提高脾肾气虚型慢性肾脏病蛋白尿的临床疗效,改善患者临床症状,减少尿蛋白排泄,延缓肾功能恶化；其可能是通过降低机体炎症细胞因子的表达而发挥肾脏保护作用。

Abstract

Objective:To evaluate the clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease (CKD) of the spleen and kidney qi deficiency type and its effect on inflammatory cytokines. Methods72 patients with proteinuria in CKD of the spleen and kidney qi deficiency type were randomly assigned into treatment group and control group, 36 patients in each group. Conventional therapy in Western medicine was given in both groups, in addition, the treatment group was treated with Qiyu Qinghua Decoction, and the control group received Shenyan Kangfu Tablets. Both groups were treated for 6 months. The clinical efficacy and the changes in the scores of syndromes in traditional Chinese medicine (TCM), 24-hour urinary protein quantification (UPro), renal function, serum albumin, blood lipids as well as inflammatory cytokines (hs-CRP, TNF-α and IL-6) were observed. Results:①=1\*GB3The total effective rate was 77.8% and 52.8% in the treatment group and the control group, respectively, and the clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ②After treatment, the scores of edema, poor appetite and abdominal distention and the total score of TCM syndrome decreased in both groups (P<0.05), and the scores of lumbar spine ache and fatigue also decreased in the treatment group (P<0.05). The scores of lumbar spine ache and fatigue and the total score of TCM syndrome were significantly lower in the treatment group than in the control group after treatment (P<0.05). ③=3\*GB3After treatment, the 24h UPro decreased significantly in both groups (P<0.05); the 24h UPro,Scr and eGFR improved in the treatment group compared to the control group (P<0.05). ④=4\*GB3After treatment, the levels of hs-CRP, TNF-α and IL-6 decreased in both groups (P<0.05); and the levels were lower in the treatment group than in the control group (P<0.05). Conclusion:Qiyu Qinghua Decoction shows improved clinical efficacy in treating proteinuria in CKD of the spleen and kidney qi deficiency type, improves clinical symptoms of the patients, reduces the excretion of urinary protein and delays the deterioration of renal function. It is possible that the drug protects the kidney by reducing the expression of inflammatory cytokines.

关键词

慢性肾脏病芪蓣清化汤蛋白尿炎症细胞因子临床疗效

Keywords

chronic kidney diseaseQiyu Qinghua Decoctionproteinuriainflammatory cytokineclinical efficacy

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