This paper introduces the clinical experience of Professor Zhou Yongming in the treatment of chronic deficiency disease with plaster prescription. He thinks that deficiency disease is caused by deficiency, and the deficiency of qi,blood,yin and yang is the important pathological factors. The deficiency disease involves five zang-organs,and the liver,spleen and kidney are the key points in the treatment. The plaster prescription, which has the action of nourishing slowly and regulating the bias of yin and yang, is effective in the treatment of deficiency disease.