Clinical study on Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediateterminal lung adenocarcinoma after chemotherapy

LIU Chang; ZHAO Xiaozhen; WANG Zhongqi; DENG Haibin; CAI Yuejiao; XU Zhenye

doi:10.16305/j.1007-1334.2019.06.013

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Clinical study on Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediateterminal lung adenocarcinoma after chemotherapy

更新时间：2022-08-31

- Clinical study on Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediateterminal lung adenocarcinoma after chemotherapy
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 6, Pages: 49-53(2019)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院肿瘤科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.06.013
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LIU Chang, ZHAO Xiaozhen, WANG Zhongqi, et al. Clinical study on Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediateterminal lung adenocarcinoma after chemotherapy. [J]. Shanghai Journal of Traditional Chinese Medicine 53(6):49-53(2019)
DOI：

LIU Chang, ZHAO Xiaozhen, WANG Zhongqi, et al. Clinical study on Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediateterminal lung adenocarcinoma after chemotherapy. [J]. Shanghai Journal of Traditional Chinese Medicine 53(6):49-53(2019) DOI： 10.16305/j.1007-1334.2019.06.013.

摘要

目的：观察肺岩宁方联合抗瘤增效方对中晚期肺腺癌患者化疗后癌因性疲乏、免疫功能及肿瘤标志物的影响。方法：将132例中晚期肺腺癌化疗后患者随机分为治疗组和对照组,每组66例。对照组予抗瘤增效方,治疗组予肺岩宁方联合抗瘤增效方。两组疗程均为3个月,观察比较癌因性疲乏量表(CFS)与简易疲乏量表(BFI)评分、免疫相关指标、肿瘤标志物(CEA、CA199、CYFRA21-1、CA125)水平的变化情况。结果：①最终完成试验者124例,其中治疗组63例,对照组61例。②组间治疗后比较,治疗组BFI评分及CFS评分中的躯体维度、情感维度、总分明显低于对照组(P,<,0.05)。③组间治疗后比较,治疗组CD3,+,、CD4,+,、CD8,+,、CD56,+,16(NK)水平明显高于对照组(P,<,0.05)。④组间治疗后比较,治疗组CYFRA21-1、CA125水平明显低于对照组(P,<,0.05)。结论：与单用抗瘤增效方相比,肺岩宁方联合抗瘤增效方可更好地改善化疗后中晚期肺腺癌患者的癌因性疲乏程度,提高其外周血淋巴细胞水平,降低血清肿瘤标志物(CYFRA21-1、CA125)水平,从而改善患者的预后及生存质量。

Abstract

Objective:To observe the effects of Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediate-terminal lung adenocarcinoma after chemotherapy. Methods132 patients with intermediate-terminal lung adenocarcinoma were randomly assigned into treatment group and control group, 66 patients in each group. The control group was given Kangliu Zengxiao Recipe and the treatment group was given Feiyanning Recipe combined with Kangliu Zengxiao Recipe. Both groups were treated for 3 months. Scores on the cancer fatigue scale (CFS) and the brief fatigue inventory (BFI) and immune-related indicators [CD3,+, CD4,+, CD8,+, CD56,+,16(NK), CD19,+,] were observed. Changes in the levels of tumor markers (CEA, CA199, CYFRA21-1 and CA125) were also evaluated. Results:①124 patients completed the trial, including 63 in the treatment group and 61 in the control group. ②The body dimension, emotional dimension and total score in the BFI and CFS scores were significantly lower in the treatment group than in the control group after treatment (P,<,0.05). ③The levels of CD3,+, CD4,+, CD8,+, and CD56,+,16 (NK) were significantly higher in the treatment group than in the control group after treatment (P,<,0.05). ④The levels of CYFRA21-1 and CA125 were significantly lower in the treatment group tha in the control group after treatment (P,<,0.05). Conclusion:Compared with Kangliu Zengxiao Recipe alone, Feiyanning Recipe combined with Kangliu Zengxiao Recipe can better improve cancer-related fatigue in patients with intermediate-terminal lung adenocarcinoma after chemotherapy, increase the levels of peripheral blood lymphocytes and lower the levels of serum tumor markers (CYFRA21-1 and CA125), thereby improving prognosis and quality of life for the patients.

关键词

肺腺癌化疗后癌因性疲乏中医药疗法免疫功能肿瘤标记物肺岩宁方

Keywords

lung adenocarcinomaafter chemotherapycancer-related fatigueChinese medicine treatmentimmune functiontumor markersFeiyanning Recipe

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