Study of distribution of TCM syndromes,Helicobacter pylori infection and pathological changes of gastric mucosa in chronic atrophic gastritis 

LI Li; ZHU Leiei; SUN Zhumei; WANG Huiwen; CONG Jun; CHEN Changzhou; GU Zhijian; LI Na

doi:10.16305/j.1007-1334.2019.06.005

您当前的位置：

首页 >

文章列表页 >

Study of distribution of TCM syndromes,Helicobacter pylori infection and pathological changes of gastric mucosa in chronic atrophic gastritis 

更新时间：2022-08-31

- Study of distribution of TCM syndromes,Helicobacter pylori infection and pathological changes of gastric mucosa in chronic atrophic gastritis 
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 6, Pages: 20-23(2019)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院脾胃科,上海,200021
  2. 上海中医药大学基础医学院,上海,201203
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.06.005
  CLC：
扫描看全文
LI Li, ZHU Leiei, SUN Zhumei, et al. Study of distribution of TCM syndromes,Helicobacter pylori infection and pathological changes of gastric mucosa in chronic atrophic gastritis . [J]. Shanghai Journal of Traditional Chinese Medicine 53(6):20-23(2019)
DOI：

LI Li, ZHU Leiei, SUN Zhumei, et al. Study of distribution of TCM syndromes,Helicobacter pylori infection and pathological changes of gastric mucosa in chronic atrophic gastritis . [J]. Shanghai Journal of Traditional Chinese Medicine 53(6):20-23(2019) DOI： 10.16305/j.1007-1334.2019.06.005.

摘要

目的：分析慢性萎缩性胃炎的中医证型分布及幽门螺杆菌(Hp)感染、胃黏膜病理变化情况。方法：收集338例慢性萎缩性胃炎患者的相关资料,分析中医证型分布及Hp感染、胃黏膜病理变化情况。结果：①慢性萎缩性胃炎患者以脾胃虚弱证最为多见(23.4%),其余依次为脾胃湿热证(20.7%)、肝胃气滞证(19.2%)、胃阴不足证(13.3%)、肝胃郁热证(12.1%)、胃络瘀血证(11.2%)。②338例慢性萎缩性胃炎患者中,Hp阳性率为55.3%,各中医证型中脾胃湿热证患者Hp阳性率最高(72.9%)；不同中医证型Hp阳性率差异有统计学意义(P<0.01)。③在胃黏膜活动性炎症方面,总检出率为 53.8%,各中医证型中脾胃湿热证患者活动性炎症检出率最高(71.4%),其中中度、重度活动性炎症占比分别为37.1%和27.1%；不同证型患者胃黏膜组织活动性炎症程度差异有统计学意义(P<0.05)。④在胃黏膜组织萎缩方面,脾胃虚弱证患者胃黏膜组织中度、重度萎缩占比最高,分别为43.0%和27.8%；不同证型患者胃黏膜组织萎缩程度差异有统计学意义(P<0.05)。⑤不同证型患者胃黏膜组织慢性炎症、肠化生程度及低级别上皮内瘤变检出率差异无统计学意义(P＞0.05)。结论：慢性萎缩性胃炎患者最常见的中医证型为脾胃虚弱,脾胃虚弱型患者胃黏膜组织中度、重度萎缩发生率较高；脾胃湿热与Hp感染密切相关,脾胃湿热型患者胃黏膜活动性炎症程度较重。

Abstract

Objective:To study the distribution of traditional Chinese medicine (TCM) syndromes,Helicobacter pylori(Hp) infection and pathological changes of gastric mucosa in chronic atrophic gastritis. MethodsThe related data of 338 patients with chronic atrophic gastritis were collected. The distribution of TCM syndromes, Hp infection and pathological changes of gastric mucosa were analyzed. Results:①The syndrome of deficiency of spleen and stomach was the most common in patients with chronic atrophic gastritis(23.4%), followed by dampness-heat of spleen and stomach (20.7%), stagnation of liver qi and stomach qi(19.2%), deficiency of stomach yin(13.3%), stagnated heat of liver and stomach(12.1%), and blood stasis in stomach collateral(11.2%).② The total Hp infection positive rate of 338 patients with chronic atrophic gastritis was 55.3%, which was highest in dampness-heat of spleen and stomach syndrome (72.9%); different syndromes of chronic atrophic gastritis had statistically significant difference in the rate of Hp infection (P<0.01) .③The total positive rate of gastric mucosa active inflammation was 53.8%, which was highest in dampness-heat of spleen and stomach syndrome(71.4%), The proportion of moderate and severe active inflammation was 37.1% and 27.1% respectively.There were statistically significant differences in the degree of active inflammation of gastric mucosa in different TCM syndromes (P<0.05).④The proportion of moderate and severe gastric mucosa atrophy in deficiency of spleen and stomach syndrome was the highest (43.0% and 27.8%, respectively).The degree of gastric mucosa atrophy in different TCM syndromes was statistically different(P<0.05).⑤There was no statistically significant difference between different TCM syndromes in chronic inflammation of gastric mucosa, intestinal metaplasia, and low-grade intraepithelial P>0.05). Conclusion:Deficiency of spleen and stomach syndrome is the most common TCM syndrome in patients with chronic atrophic neoplasia (gastritis, which has the higher incidence of moderate and severe gastric mucosa atrophy; dampness-heat of spleen and stomach syndrome is closely related to Hp infection, and the degree of gastric mucosa active inflammation is also more severe.

关键词

慢性萎缩性胃炎中医证型幽门螺杆菌病理

Keywords

chronic atrophic gastritistraditional Chinese medicine syndromesHelicobacter pyloripathology

references

Views

710

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical efficacy of Cai Gan’s treatment of chronic atrophic gastritis： a real world study

A retrospective cohort study on Compound Jiaogulan Capsule for prevention of oral leukoplakia canceration based on prognostic analysis

Treatment of 32 cases of chronic atrophic gastritis with qi deficiency and blood stasis by modified Weiqi Decoction

Jianpi Jiedu Recipe down-regulates angiogenic factors in Helicobacter pylori-induced gastric cancer cells by inhibiting Wnt/β-catenin signaling pathway

Analysis on the distribution of chronic gastritis in TCM syndromes and Helicobacter pylori infection

Related Author

No data

Related Institution

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

Department of Oral Mucosal Diseases, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

Spleen-Stomach Disease Department,Longhua Hospital,Shanghai University of Traditiongal Chinese Medicine

Department of Oncology,Cancer Institute of Integrated Chinese and Western Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

⁰