Clinical study on effects of modified Wuhu Zhuifeng powder on serum levels of IL-1β, Cys-C and Hcy and motor symptoms in patients with Parkinson’s disease

HUANG Shaodong; LIANG Jianfen; ZHANG Xingbo; YANG Xianchao; ZHOU Huamei; XU Liuyan

doi:10.16305/j.1007-1334.2019.05.016

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Clinical study on effects of modified Wuhu Zhuifeng powder on serum levels of IL-1β, Cys-C and Hcy and motor symptoms in patients with Parkinson’s disease

更新时间：2022-08-31

- Clinical study on effects of modified Wuhu Zhuifeng powder on serum levels of IL-1β, Cys-C and Hcy and motor symptoms in patients with Parkinson’s disease
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 5, Pages: 60-63(2019)
- 作者机构：
  
  1. 广西中医药大学研究生院,广西,南宁,530001
  2. 广西中医药大学第一附属医院老年病科,广西南宁,530023
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.05.016
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HUANG Shaodong, LIANG Jianfen, ZHANG Xingbo, et al. Clinical study on effects of modified Wuhu Zhuifeng powder on serum levels of IL-1β, Cys-C and Hcy and motor symptoms in patients with Parkinson’s disease. [J]. Shanghai Journal of Traditional Chinese Medicine 53(5):60-63(2019)
DOI：

HUANG Shaodong, LIANG Jianfen, ZHANG Xingbo, et al. Clinical study on effects of modified Wuhu Zhuifeng powder on serum levels of IL-1β, Cys-C and Hcy and motor symptoms in patients with Parkinson’s disease. [J]. Shanghai Journal of Traditional Chinese Medicine 53(5):60-63(2019) DOI： 10.16305/j.1007-1334.2019.05.016.

摘要

目的：观察加味五虎追风散对帕金森病患者血清白细胞介素-1β(IL-1β)、胱抑素-C(Cys-C)、同型半胱氨酸(Hcy)水平及运动症状的影响。方法：将108例帕金森病患者随机分为治疗组和对照组,每组54例。对照组予多巴丝肼片,治疗组在多巴丝肼片基础上加用加味五虎追风散。两组疗程均为3个月,观察用药安全性,比较血清IL-1β、Cys-C、Hcy水平,以及统一帕金森病评分量表(UPDRS)、帕金森病生活质量量表(PDQ-39)评分的变化情况。结果：①最终完成试验者104例,治疗组53例、对照组51例。 ②治疗前后组内比较,两组UPDRSⅡ、UPDRSⅢ、UPDRSⅣ评分及PDQ-39量表评分均明显减少(P<0.05)；组间治疗后比较,治疗组各项评分均明显低于对照组(P<0.05)。③治疗前后组内比较,两组IL-1β、Cys-C及Hcy水平均明显降低(P<0.05)；组间治疗后比较,治疗组IL-1β、Cys-C及Hcy水平明显低于对照组(P<0.05)。④两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论：加味五虎追风散治疗帕金森病,能有效降低患者血清IL-1β、Cys-C、Hcy水平,显著改善患者的运动症状,减轻西药的不良反应,进而有利于提高生活质量。

Abstract

Objective:To observe the effects of modified Wuhu Zhuifeng powder on serum levels of interleukin (IL)-1β, Cystatin (Cys)-C and homocystein (Hcy) and motor sysmptoms in patients with Parkinson’s disease (PD). Methods108 patients with PD were randomly assigned into treatment group and control group, 54 patients in each group. Patients in both groups were given levodopa and benserazide hydrochloride tablets, and the treatment group was given modified Wuhu Zhuifeng powder in addition. The course of treatment was 3 months. Medication safety was observed. Changes in the serum levels of IL-1β, Cys-C and Hcy, and in scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) and Parkinson’s Disease Questionnaire (PDQ-39) were compared. Results:①104 patients completed the trial, including 53 and 51 patients in the treatment group and the control group respectively. ②After treatment, the UPDRSⅡ, UPDRSⅢ, UPDRSⅣ and PDQ-39 scores decreased significantly in both groups compared to those before treatment (P<0.05). The scores were significantly lower in the treatment group than in the control group after treatment (P<0.05). ③After treatment, the levels of IL-1β, Cys-C and Hcy decreased in both groups compared to those before treatment (P<0.05). The levels were significantly lower in the treatment group than in the control group after treatment (P<0.05). ④There were no significant differences in the incidence of adverse drug reactions between the groups (P>0.05). Conclusion:In treating PD, modified Wuhu Zhuifeng powder can effectively lower the serum levels of IL-1β, Cys-C and Hcy, significantly relieve the motor symptoms, reduce the adverse reactions of western medicine and improve the quality of life of the patients.

关键词

帕金森病加味五虎追风散白细胞介素-1β胱抑素C同型半胱氨酸运动症状增效减毒

Keywords

Parkinson’s diseasemodified Wuhu Zhuifeng Powderinterleukin-1βcystatin-Chomocysteinemotor symptomssynergism and attenuation

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