Observation on efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in treating cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer 

SU Wan; WANG Zhongqi; DENG Haibin; ZHAO Xiaozhen; WANG Lifang; WU Ji; WANG Shaomo; CAI Yuejiao; XU Zhenye

doi:10.16305/j.1007-1334.2019.05.014

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Observation on efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in treating cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer 

更新时间：2022-08-31

- Observation on efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in treating cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer 
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 5, Pages: 53-56(2019)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院肿瘤科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.05.014
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SU Wan, WANG Zhongqi, DENG Haibin, et al. Observation on efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in treating cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer . [J]. Shanghai Journal of Traditional Chinese Medicine 53(5):53-56(2019)
DOI：

SU Wan, WANG Zhongqi, DENG Haibin, et al. Observation on efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in treating cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer . [J]. Shanghai Journal of Traditional Chinese Medicine 53(5):53-56(2019) DOI： 10.16305/j.1007-1334.2019.05.014.

摘要

目的：观察抗瘤减毒方联合参芪扶正注射液改善中晚期非小细胞肺癌患者癌因性疲乏的疗效。方法：将80例中晚期非小细胞肺癌癌因性疲乏患者随机分为治疗组和对照组,每组40例。两组患者均予化疗,对照组在化疗的基础上加服四君子汤或沙参麦冬汤,治疗组在化疗的基础上加用抗瘤减毒方及参芪扶正注射液。两组疗程均为16周,比较Piper疲乏量表评分、癌症生活质量问卷(QLQ-C30)评分、血常规、自然杀伤(NK)细胞、T淋巴细胞亚群(CD3,+,、CD4,+,、CD8,+,、CD4,+, /CD8,+,)、白介素-6(IL-6)水平的变化情况。结果：①=1\*GB3治疗组脱落2例,对照组脱落3例,最终完成试验者75例,其中治疗组38例,对照组37例。②组间治疗后比较,治疗组疲乏症状改善情况优于对照组(P,<,0.05),生活质量高于对照组(P,<,0.05)。③=3\*GB3治疗前后组内比较,两组血红蛋白、白细胞水平及中性粒细胞绝对值均较治疗前降低(P,<,0.05)；组间治疗后比较,治疗组血红蛋白、白细胞水平及中性粒细胞绝对值高于对照组(P,<,0.05)。④治疗前后组内比较,治疗组各免疫指标(NK、CD3,+,、CD4,+,、CD8,+,、CD4,+,/CD8,+,、IL-6)水平差异无统计学意义(P,>,0.05),对照组上述免疫指标水平差异有统计学意义(P,<,0.05)；组间治疗后比较,治疗组NK、CD4,+,、IL-6水平及CD4,+,/CD8,+,值高于对照组(P,<,0.05)。结论：抗瘤减毒方联合参芪扶正注射液能明显改善中晚期非小细胞肺癌患者的疲乏症状,提高生活质量,其机制可能与缓解骨髓抑制、调节免疫功能有关。

Abstract

Objective:To observe the clinical efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in improving cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer (NSCLC). Methods80 NSCLC patients with cancer-related fatigue were randomly assigned into treatment group and control group, 40 patients in each group. Both groups were given chemotherapy, and during chemotherapy the control group was administered Sijunzi decoction or Shashen Maidong decoction, and the treatment group was treated with Kangliu Jiandu recipe combined with Shenqi Fuzheng injection. The course of treatment was 16 weeks. Changes in the scores on Piper fatigue scale, the Quality of Life Questionnaire-Cancer (QLQ-C30) scores, blood routine, natural killer (NK) cells, T lymphocyte subsets (CD3,+, CD4,+, CD8,+, CD4,+, /CD8,+,), interleukin-6 (IL-6) levels were compared between the two groups. Results:①=1\*GB3There were 2 and 3 drop-outs in the treatment group and the control group respectively. 75 patients completed the trial, including 38 and 37 patients in the treatment group and the control group respectively. ②After treatment, there was better improvement of fatigue symptoms in the treatment group than in the control group (P,<,0.05), and the quality of life was higher in the treatment group than in the control group (P,<,0.05). ③=3\*GB3After treatment, the levels of hemoglobin, white blood cells and absolute neutrophils were reduced in both groups compared to those before treatment (P,<,0.05); and the levels were higher in the treatment group than in the control group (P,<,0.05). ④There were no significant differences in the levels of immune indexes (NK, CD3,+, CD4,+, CD8,+, CD4,+,/CD8,+, IL-6) in the treatment group before and after treatment (P,>,0.05), while the levels showed significant differences in the control group before and after treatment (P,<,0.05). The levels of NK, CD4,+, IL-6 and CD4,+,/CD8,+, were higher in the treatment group than in the control group after treatment (P,<,0.05). Conclusion:Kangliu Jiandu recipe combined with Shenqi Fuzheng injection can significantly improve the fatigue symptoms and quality of life in patients with intermediate-terminal non-small cell lung cancer, and the mechanism of action may be related to relieving bone marrow depression and regulating immune function.

关键词

非小细胞肺癌癌因性疲乏抗瘤减毒方参芪扶正注射液T淋巴细胞亚群

Keywords

non-small cell lung cancercancer-related fatigueKangliu Jiandu RecipeShenqi Fuzheng injectionT lymphocyte subsets

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