Objective:To detect the hemorheological indicators and expression of pro-angiogenic factors in blood stasis syndrome and non-blood stasis syndrome of patients with colorectal cancer (CRC), and analyze the relationship between blood stasis syndrome and blood hypercoagulability as well as tumor angiogenesis. Methods839 patients including retrospective and prospective cases were assigned into blood stasis syndrome group and non-blood stasis syndrome group. The hemorheological indicators in the whole blood of the patients were measured by plasma separation technique, and the changes of these indicators were analyzed. The expression of pro-angiogenic factors (Angiogenin, ANG-2, EGF, bFGF, HB-EGF, HGF, Leptin, PDGF-BB, PIGF and VEGF) in serum was detected by protein chip technique, and differences in expression were analyzed.  Results:①In general, the proportion of patients with blood stasis syndrome and non-blood stasis syndrome was about 1∶4 in CRC patients. ②The preoperative erythrocyte sedimentation rate and K value of blood sedimentation equation in the blood stasis syndrome group were significantly higher than normal value in both male and female patients, and were also significantly higher than the corresponding levels in the non-blood stasis syndrome group (P<0.05). Meanwhile, the post-operative erythrocyte sedimentation rate and K value of blood sedimentation equation also presented consistent changes, and the corresponding levels of males and females in the blood stasis syndrome group were significantly higher than those in the non- blood stasis syndrome group (P<0.05). ③The average fibrinogen level of males and females in the blood stasis syndrome group was significantly higher than that in the non-blood stasis syndrome group in preoperative CRC patients (P<0.05). The post-operative fibrinogen levels of males and females in both groups were within the normal range on average, with no statistically significant differences between the groups (P>0.05). ④The expression levels of Angiogenin, Ang-2, EGF, bFGF, HB-EGF, HGF, Leptin, PDGF-BB, PIGF and VEGF in serum were significantly higher in the blood stasis syndrome group than in the non-blood stasis syndrome group in CRC patients (P<0.05).  Conclusion:Compared to CRC patients with non-blood stasis syndrome, those with blood stasis syndrome showed a high coagulation state, and the expression of pro-angiogenic factors was significantly higher, suggesting a close relationship between blood stasis syndrome in traditional Chinese medicine and tumor angiogenesis in western medicine.