Effect of acupuncture combined with Western medicine on levels of T lymphocyte subsets, IL-4, IL-10 and VACM-1 in patients with moderate to severe intermittent allergic rhinitis

WANG Yingying; ZHU Bei; GAO Juan; YAO Keqing

doi:10.16305/j.1007-1334.2019.04.016

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Effect of acupuncture combined with Western medicine on levels of T lymphocyte subsets, IL-4, IL-10 and VACM-1 in patients with moderate to severe intermittent allergic rhinitis

更新时间：2022-08-31

- Effect of acupuncture combined with Western medicine on levels of T lymphocyte subsets, IL-4, IL-10 and VACM-1 in patients with moderate to severe intermittent allergic rhinitis
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 4, Pages: 57-60(2019)
- 作者机构：
  
  1. 新汶矿业集团有限责任公司中心医院检验科,山东,泰安,271219
  2. 新汶矿业集团有限责任公司中心医院理疗科,山东,泰安,271219
  3. 山东省聊城市人民医院耳鼻喉科,山东聊城,252000
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.04.016
  CLC：
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WANG Yingying, ZHU Bei, GAO Juan, et al. Effect of acupuncture combined with Western medicine on levels of T lymphocyte subsets, IL-4, IL-10 and VACM-1 in patients with moderate to severe intermittent allergic rhinitis. [J]. Shanghai Journal of Traditional Chinese Medicine 53(4):57-60(2019)
DOI：

WANG Yingying, ZHU Bei, GAO Juan, et al. Effect of acupuncture combined with Western medicine on levels of T lymphocyte subsets, IL-4, IL-10 and VACM-1 in patients with moderate to severe intermittent allergic rhinitis. [J]. Shanghai Journal of Traditional Chinese Medicine 53(4):57-60(2019) DOI： 10.16305/j.1007-1334.2019.04.016.

摘要

目的：观察针灸联合西药对中重度间歇性过敏性鼻炎患者血清T淋巴细胞亚群、炎性因子及血管细胞黏附分子-1(VACM-1)的影响。方法：将120例中重度间歇性过敏性鼻炎患者随机分为对照组和治疗组,每组60例。对照组予丙酸氟替卡松鼻喷雾剂、盐酸氮卓斯汀片治疗,治疗组在对照组治疗措施的基础上加用针灸疗法。两组疗程均为28天,观察临床疗效,比较中医证候积分、血清T淋巴细胞亚群、炎性因子及VACM-1水平的变化情况。结果：①=1\*GB3治疗组、对照组总有效率分别为95.0%、81.7%,治疗组临床疗效优于对照组(P,<,0.05)。②=2\*GB3治疗前与疗程结束后7天组内比较,两组中医证候(鼻塞不通、鼻痒难耐、鼻流清涕、喷嚏频作)较治疗前改善(P,<,0.05)；组间疗程结束后7天比较,治疗组中医证候改善情况优于对照组(P,<,0.05)。③=3\*GB3治疗前与疗程结束后7天组内比较,两组血清CD3,+,、CD4,+,水平和CD4,+,/CD8,+,较治疗前升高(P,<,0.05),血清CD8,+,、IL-4、IL-10、VCAM-1水平较治疗前降低(P,<,0.05)；组间疗程结束后7天比较,上述指标差异有统计学意义(P,<,0.05)。结论：针灸联合西医治疗中重度间歇性过敏性鼻炎疗效满意,可有效缓解患者的临床症状,改善机体免疫状态,减轻炎症反应。

Abstract

Objective:To observe the effect of acupuncture combined with Western medicine on serum T lymphocyte subsets, inflammatory factors and vascular cell adhesion molecule-1 (VACM-1) in patients with moderate to severe intermittent allergic rhinitis. Methods120 patients with moderate to severe intermittent allergic rhinitis were randomly assigned into control group and treatment group, 60 patients in each group. The control group was treated with fluticasone propionate nasal spray and azostatin hydrochloride tablets, and the treatment group was given acupuncture on top of treatment in the control group. Treatment duration was 28 days. Clinical efficacy was observed and changes in TCM syndrome score, serum T lymphocyte subsets, inflammatory factors [interleukin-4 (IL-4) and interleukin-10 (IL-10)] and VACM-1 levels were compared. Results:①The total effective rate was 95.0% and 81.7% in the treatment and control groups, respectively. The clinical efficacy in the treatment group was superior to that in the control group (P,<,0.05). ②At 7 days after treatment, the TCM syndromes in both groups (stuffy nose, intolerably itchy nose, runny nose and frequent sneezing) were improved compared to those before treatment. There was better improvement in the treatment group than in the control group at 7 days after treatment (P,<,0.05). ③At 7 days after treatment, in both groups, the levels of serum CD3,+, CD4,+, CD4,+,/CD8,+, increased compared to those before treatment (P,<,0.05), while the levels of serum CD8,+, IL-4, IL-10 and VCAM-1 were lower than those before treatment (P,<,0.05). There were significant differences in the above indicators between the groups at 7 days after treatment (P,<,0.05). Conclusion:Acupuncture combined with Western medicine shows satisfactory effect in the treatment of moderate to severe intermittent allergic rhinitis. It can effectively alleviate the clinical symptoms of patients, improve the immune status of the body and reduce inflammatory reactions.

关键词

中重度间歇性过敏性鼻炎针灸T淋巴细胞亚群白介素-4白介素-10血管细胞黏附分子-1

Keywords

moderate to severe intermittent allergic rhinitisacupunctureT lymphocyte subsetsinterleukin-4interleukin-10vascular cell adhesion molecule-1

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