Effect of Jianpi Xiaozhuo Decoction on serum hypersensitive C-reactive protein in patients with metabolic syndrome of phlegm-stasis type

ZHAO Xiao; SUN Yichun; FENG Chunlin; GU Luyan; ZHANG Yuelei

doi:10.16305/j.1007-1334.2019.04.013

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Effect of Jianpi Xiaozhuo Decoction on serum hypersensitive C-reactive protein in patients with metabolic syndrome of phlegm-stasis type

更新时间：2022-08-31

- Effect of Jianpi Xiaozhuo Decoction on serum hypersensitive C-reactive protein in patients with metabolic syndrome of phlegm-stasis type
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 4, Pages: 50-53(2019)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院天山分院中医内科,上海,200051
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.04.013
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ZHAO Xiao, SUN Yichun, FENG Chunlin, et al. Effect of Jianpi Xiaozhuo Decoction on serum hypersensitive C-reactive protein in patients with metabolic syndrome of phlegm-stasis type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(4):50-53(2019)
DOI：

ZHAO Xiao, SUN Yichun, FENG Chunlin, et al. Effect of Jianpi Xiaozhuo Decoction on serum hypersensitive C-reactive protein in patients with metabolic syndrome of phlegm-stasis type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(4):50-53(2019) DOI： 10.16305/j.1007-1334.2019.04.013.

摘要

目的：观察健脾消浊汤对痰瘀型代谢综合征患者血清超敏C反应蛋白(hs-CRP)的影响。方法：将64例痰瘀型代谢综合征患者随机分为对照组(32例)、治疗组(32例),对照组予改善生活方式及运动治疗,治疗组在对照组治疗措施的基础上加用健脾消浊汤。两组疗程均为3个月,观察临床疗效,比较中医证候积分、腰围、血清hs-CRP水平的变化情况。结果：①=1\*GB3治疗组、对照组总有效率分别为84.4%、50.0%,治疗组临床疗效优于对照组(P<0.05)。②=2\*GB3治疗前后组内比较,两组中医证候积分、腰围较治疗前减少(P<0.05)；组间治疗后比较,治疗组中医证候积分少于对照组(P<0.05),腰围小于对照组(P<0.05)；组间中医证候积分、腰围治疗前后差值比较,治疗组大于对照组(P<0.05)。③=3\*GB3治疗前后组内比较,两组血清hs-CRP水平较治疗前降低(P<0.05)；组间治疗后比较,治疗组血清hs-CRP水平低于对照组(P<0.05)；组间血清hs-CRP治疗后差值比较,治疗组大于对照组(P<0.05)。④=4\*GB3Pearson相关性分析结果显示,患者血清hs-CRP水平下降幅度与腰围下降幅度(r=0.410,P=0.016)及中医证候积分下降幅度(r=0.492,P=0.024)均成正性弱相关。结论：健脾消浊汤治疗痰瘀型代谢综合征疗效满意,可明显改善患者的临床症状,减轻低度炎症反应。

Abstract

Objective:To observe the effect of Jianpi Xiaozhuo Decoction on serum hypersensitive C-reactive protein (hs-CRP) in patients with metabolic syndrome of the phlegm-stasis type. Methods64 patients with metabolic syndrome of phlegm-stasis type were randomly assigned into control group (32 patients) and treatment group (32 patients). Improved lifestyle and exercise therapy were given to the control group and Jianpi Xiaozhuo Decoction was administered to patients in the treatment group on top of the treatment in the control group. Treatment duration was 3 months. Clinical efficacy was observed. Changes in TCM syndrome score, waist circumference and serum hs-CRP level were compared. Results:①=1\*GB3The total effective rate was 84.4% and 50.0% in the treatment and control groups, respectively. The clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ②=2\*GB3After treatment, TCM syndrome scores and waist circumference decreased in both groups (P<0.05); they were lower in the treatment group than in the control group (P<0.05). The differences in TCM syndrome scores and waist circumference were greater in the treatment group than in the control group compared to those before treatment (P<0.05). ③=3\*GB3After treatment, the level of serum hs-CRP decreased in both groups (P<0.05); it was lower in the treatment group than in the control group (P<0.05). The difference in hs-CRP level was greater in the treatment group than in the control group (P<0.05). ④=4\*GB3Pearson correlation analysis showed that the degree of decline in serum hs-CRP level was weakly positively correlated with decrease in waist circumference (r=0.410, P=0.016) and TCM syndrome score (r=0.492, P=0.024). Conclusion:Jianpi Xiaozhuo Decoction shows satisfactory effect in treating metabolic syndrome of the phlegm stasis type. It can significantly improve the clinical symptoms of patients and reduce low-grade in flammatory reactions.

关键词

代谢综合征痰瘀型健脾消浊汤超敏C反应蛋白

Keywords

metabolic syndromephlegm-stasis typeJianpi Xiaozhuo Decoctionhypersensitive C-reactive protein

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