Effects of Wushen Oral Liquid on autonomic nervous function in patients after PCI for myocardial infarction of qi-yin deficiency type

WANG Huiying; CUI Song; HUANG Lanxun; RUAN Xiaofen; WU Fangyi

doi:10.16305/j.1007-1334.2019.03.012

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Effects of Wushen Oral Liquid on autonomic nervous function in patients after PCI for myocardial infarction of qi-yin deficiency type

更新时间：2022-08-31

- Effects of Wushen Oral Liquid on autonomic nervous function in patients after PCI for myocardial infarction of qi-yin deficiency type
- Shanghai Journal of Traditional Chinese Medicine Vol. 53, Issue 3, Pages: 47-50(2019)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院心内科,上海,200021
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2019.03.012
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WANG Huiying, CUI Song, HUANG Lanxun, et al. Effects of Wushen Oral Liquid on autonomic nervous function in patients after PCI for myocardial infarction of qi-yin deficiency type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(3):47-50(2019)
DOI：

WANG Huiying, CUI Song, HUANG Lanxun, et al. Effects of Wushen Oral Liquid on autonomic nervous function in patients after PCI for myocardial infarction of qi-yin deficiency type. [J]. Shanghai Journal of Traditional Chinese Medicine 53(3):47-50(2019) DOI： 10.16305/j.1007-1334.2019.03.012.

摘要

目的：观察五参口服液联合西医常规疗法对气阴两虚型心肌梗死PCI术后患者自主神经功能的影响。方法：将70例气阴两虚型心肌梗死PCI术后患者随机分为治疗组和对照组,每组35例。对照组予西医常规疗法,治疗组予西医常规疗法联合中药五参口服液。两组疗程均为3个月,观察中医证候疗效、自主神经功能指标(心率变异性、心率减速力)的变化情况。结果：①治疗组、对照组总有效率分别为97.1%、88.6%,治疗组中医证候疗效优于对照组(P<0.05)。②与本组治疗前比较,治疗组SDNN、SDANN、rMMSD、PNN50水平明显升高(P<0.05),对照组SDNN、rMMSD水平明显升高(P<0.05)；治疗后组间比较,治疗组SDNN、SDANN、rMMSD水平明显高于对照组(P<0.05)。③与本组治疗前比较,两组治疗后心率减速力值均明显升高(P<0.05)；治疗后组间比较,心率减速力值差异无统计学意义(P>0.05)。结论：五参口服液联合西医常规疗法可改善气阴两虚型心肌梗死PCI术后患者的中医证候,升高心率变异指标SDNN、SDANN、rMMSD,趋势性升高心率减速力,从而使患者的自主神经功能趋于平衡。

Abstract

Objective:To observe the effects of Wushen Oral Liquid combined with conventional Western medicine therapy on autonomic nervous function in patients after percutaneous coronary intervention (PCI) for myocardial infarction (MI) of the qi-yin deficiency type. Methods70 patients after PCI for MI of the qi-yin deficiency type were randomly assigned into treatment group and control group, 35 patients in each group. Conventional Western medicine therapy was given to the control group and its combination with Wushen Oral Liquid was administered to the treatment group. The treatment course was 3 months in both groups. Therapeutic effect on TCM syndromes was observed and changes in measures of autonomic nervous function (variability and deceleration capacity of heart rate) were compared. Results:①The overall effective rate was 97.1% and 88.6% in the treatment and control groups respectively. The therapeutic effect on TCM syndromes in the treatment group was significantly superior to that in the control group (P<0.05). ②The levels of SDNN, SDANN, rMMSD and PNN50 increased significantly in the treatment group (P<0.05) and the levels of SDNN and rMMSD increased significantly in the control group (P<0.05) after treatment compared to those before treatment. The levels of SDNN, SDANN and rMMSD were significantly higher in the treatment group than in the control group after treatment (P<0.05). ③The deceleration capacity of heart rate increased significantly in both groups after treatment compared to that before treatment (P<0.05). There was no significant difference in deceleration capacity of heart rate between the groups after treatment (P>0.05). Conclusion:Wushen Oral Liquid in combination with conventional Western medicine therapy improves the TCM syndrome of patients after PCI for MI of the qi-yin deficiency type, and balances the autonomic nervous function by increasing the measures for heart rate variability (SDNN, SDANN and rMMSD) and tending to elevate the deceleration capacity of heart rate.

关键词

心肌梗死经皮冠状动脉介入术气阴两虚中西医结合疗法五参口服液自主神经功能

Keywords

myocardial infarctionpercutaneous coronary interventionqi-yin deficiencyintegrated traditional Chinese and Western medicine therapyWushen Oral Liquidautonomic nervous function

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