Objective:To observe the distribution characteristics of knee nodal points in patients with knee osteoarthritis (KOA) of the anemofrigid-damp arthralgia type and the effect of Duhuo Jisheng Decoction combined with manipulation of the nodal points. Methods80 patients with KOA of the anemofrigid-damp arthralgia type were randomly assigned into the treatment group and the control group, 40 patients in each group. Patients in the control group were treated with western medicine, and those in the treatment group received Duhuo Jisheng Decoction combined with manipulation of the nodal points in addition. Patients in both groups were treated for 4 weeks and followed up for 8 weeks. The nodal points were examined by palpitation before treatment, and the degree of tenderness was scored. The changes in scores on the Western Ontario and McMaster Universities (WOMAC) osteoarthritis scale and scores in the five-times-sit-to-stand test (FTSST) were observed.  Results:① 78 subjects completed the trial, including 38 in the treatment group and 40 in the control group. ② By palpation, it was found that 92.5% of patients with KOA of the anemofrigid-damp arthralgia type had nodal points around the knee, mainly distributed in the medial knee joint, such as medial depression of patellar ligament, pes anserinus, adductor tubercle and medial collateral ligament; and in the lateral knee joint, it is mainly distributed in the depression on the outside of the knee. Overall, there were obviously more nodal points in the medial knee than in the lateral knee, and the degree of tenderness in the medial knee was also significantly higher than that in the lateral knee. ③ The scores of pain, stiffness and joint function and the total score deceased significantly in the treatment group after treatment compared to those before treatment and at 8 weeks of follow up compared to those before treatment; and except for the stiffness score, the other scores decreased significantly in the control group (P<0.05). The pain score showed a tendency of decline in the treatment group, and the other scores showed a tendency of increase to varying degrees at 8 weeks of follow up compared to those after treatment, but there were no statistically significant differences (P>0.05); and the scores of pain and joint function and the total score increased significantly in the control group (P<0.05). There were significant differences in the scores of pain, stiffness and joint function and the total score between the groups after treatment and at 8 weeks of follow up, and the scores were significantly lower in the treatment group than in the control group (P<0.05). ④ The FTSST score decreased significantly in both groups after treatment compared to that before treatment and at 8 weeks of follow up compared to that before treatment (P<0.05); and the FTSST score increased significantly in the control group at 8 weeks of follow up compared to that after treatment (P<0.05). The FTSST score was significantly lower in the treatment group than in the control group after treatment and at 8 weeks of follow up (P<0.05).  Conclusion:Compared to treatment with western medicine, treatment with western medicine plus manipulation of the nodal points and Duhuo Jisheng Decoction is more effective in treating KOA of the anemofrigid-damp arthralgia type and it significantly improves the pain, stiffness and function of the knee with stable treatment effect.