Objective:To observe the clinical efficacy of Wenshen Buxu Decoction combined with levothyroxine sodium in the treatment of subclinical hypothyroidism (SCH) and its effect on blood lipids and related cytokine levels. MethodsA total of 86 SCH patients were randomly divided into treatment group and control group,43 cases in each group. The control group was treated with levothyroxine sodium tablets,and the treatment group was treated with Wenshen Bushu Decoction based on the treatment of the control group. The two groups were treated for 3 months. The clinical efficacy was observed and the interleukin-2 (IL-2),interleukin-10 (IL-10),interleukin-2 receptor (IL-2R) as well as the thyroid function related indicators including serum thyroid stimulating hormone (TSH),serum free triiodothyronine (FT,3,),serum free thyroxine (FT,4,),the blood lipids indexes including triglycerides (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C)]in the two groups were compared.  Results:①The total effective rate of the treatment group had significantly statistical difference compared with that of the control group (93.02% vs 74.42%,P,<,0.05)；②After treatment,the TSH level was decreased (P,<,0.05),while the serum FT,3, and FT,4, levels were increased (P,<,0.05),with statistic difference between the two groups (P,<,0.05).③After treatment,the serum TG,TC and LDL-C levels were decreased (P,<,0.05),while the HDL-C level was increased (P,<,0.05),with statistic difference between the two groups (P,<,0.05).④After treatment,the serum IL-10 levels were increased (P,<,0.05),and the IL-2 and IL-2R levels were decreased (P,<,0.05),with statistic difference between the two groups (P,<,0.05).  Conclusion:Compared with the single application of levothyroxine sodium,Wenshen Buxu Decoction combined with levothyroxine sodium can ameliorate the thyroid function and regulate the levels of blood lipids and related cytokines for SCH patients.