Objective:To observe the effect of catgut implantation at acupoint on glycolipid metabolism in patients of impaired glucose regulation (IGR) with abdominal obesity on the basis of lifestyle intervention or lifestyle intervention and metformin. MethodsA total of 160 IGR patients with abdominal obesity were randomly divided into four groups with 40 cases in each group.The group A took general dietary control and exercise advice.In addition to dietary control and exercise advice,metformin or catgut implantation at acupoint or combination of two treatments were administrated in the group B,C,D respectively. The course of treatment in each group was 6 months. The outcome was observed of IGR patients’ transition to the condition of diabetes mellitus (DM) or normal glucose tolerance (NGT) and the data were compared of the glycosylated hemoglobin (HbA1c),serum lipids (TC,TG,LDL-C,HDL-C),fasting blood glucose,plasma insulin,the relative indexes of liver function and the changes of waist circumference (WC),height and body mass level. The changes of insulin resistance index (HOMA-IR) and fatty liver index (FLI),) visceral fat index (VAI) were calculated and compared.  Results:①A total of 156 patients completed the trial,including 40 cases in the group A,37 cases in the group B,40 cases in the group C and 39 cases in the group D. ②Compared with those before treatment,the levels of HbAlc,HOMA-IR,TG,LDL,WC,BMI and FLI were significantly decreased in the group B,C,D (P<0.05,P<0.01). The level of BMI,FLI in the group A was significantly lower than that before treatment (P<0.05),and only the level of VAI in the group C and D was decreased (P<0.05). Compared with the group A after treatment,the levels of HbA1c,TG were significantly lower in the group B,C and D (P<0.05,P<0.01) and the levels of WC,FLI,VAI were significantly lower in the group C and D (P<0.01). Only the level of HOMA-IR in the group D was significantly lower than that in the group A after treatment (P<0.01). The FLI,VAI of the group C and D were significantly lower than those of the group B after treatment (P<0.05,P<0.01).③ Comparing two groups after treatment,the incidence of IGR reverse to NGT in the group B,C and D was significantly higher than that in the group A (P<0.01),and the incidence of IGR conversion to DM in the group B,C and D was significantly lower than that in the group A (P<0.01). Compared with the group B,the incidence of IGR reverse to NGT in the group C and D was significantly higher (P<0.01),and the incidence of IGR conversion to DM in the group D was significantly lower(P<0.01).④There was no significant difference in the incidence of adverse reactions among the groups (P>0.05).  Conclusion:Whether on the basis of lifestyle intervention or on the basis of lifestyle intervention and metformin,the catgut implantation at acupoint has a better regulating effect on glucose metabolism and pancreatic islet function in the treatment of IGR patients with abdominal obesity. At the same time,it can reduce abdominal obesity,the accumulation of visceral fat and hepatic fatty lesions,thereby preventing cardiovascular complications and reducing the incidence of diabetes.